中国化学快报

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A new and efficient method for the synthesis of isoquinoline-3-carboxylate

Xiang Wei Liao, Bao He Guan, Zhan Zhu Liu

中国化学快报. 2008, 19(03): 253-255. https://doi.org/10.1016/j.cclet.2007.12.025

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An isoquinoline-3-carboxylate compound 3 was obtained with a moderate yield of 40% when N-acetyl-(3'-hydroxy-4'-methoxy-5'-methyl) phenylalanine methyl ester 1 was refluxed in HMTA/TFA. However, the anticipated product N-acetyl-(3'-hydroxy-4'-methoxy-5'-methyl-6'-formyl) phenylalanine methyl ester 2 could not be found. The possible mechanism was discussed in this article.

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An enantioselective formal synthesis of (-)-thujopsene

Chen Xi Zhang, Li Jing Fang, Fu Qiang Bi, Yu Lin Li

中国化学快报. 2008, 19(03): 256-258. https://doi.org/10.1016/j.cclet.2008.01.009

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Dihydromayurone (3), a key intermediate to synthesize (-)-thujopsene (1), was efficient enantiocontrolled synthesized from (+)-dihydrocarvone through 9 steps in an overall yield of 19.3%. The key step was the Simmons-Smith reaction.

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Synthesis of 14-epi-19-nor-22-oxa-1α, 25-dihydroxyvitamin D₃

Wei Fan, Li Hai, Yong Wu

中国化学快报. 2008, 19(03): 259-260. https://doi.org/10.1016/j.cclet.2007.12.018

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The synthesis of 14-epi-19-nor-22-oxa-1α, 25(OH)₂D₃ 5 was started from diol 8 via Fall's method, oxidation, epimerization, protection, coupling with the 19-nor-A-ring 7, and then deprotection of the hydroxyl functions.

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Synthesis of novel chiral phosphine-triazine ligand derived from α-phenylethylamine for Pd-catalyzed asymmetricallylic alkylation

Jia Di Huang, Xiang Ping Hu, Zhuo Zheng

中国化学快报. 2008, 19(03): 261-263. https://doi.org/10.1016/j.cclet.2007.12.027

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A novel chiral phosphine-triazine ligand was synthesized from chiral α-phenylethylamine through a three-step procedure. In a model reaction of Pd-catalyzed allylic alkylation of rac-1, 3-diphenylprop-2-en-1-yl pivalate with dimethyl malonate, good enantioselectivity (90% e.e.) was obtained by using this ligand.

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Design, synthesis and antifungal activities in vitro of novel tetralin compounds

Hui Tang, You Jun Zhou, Yao Wu Li, Jia Guo Lv, Can Hui Zheng, Jun Chen, Ju Zhu

中国化学快报. 2008, 19(03): 264-268. https://doi.org/10.1016/j.cclet.2007.12.031

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Novel chiral tetralin compounds were designed and synthesized, and their antifungal activities in vitro were tested. The results showed that all of target compounds had potent antifungal activities, and were stronger than that of control compounds tetrahydroisoquinolines. The binding model of lead molecules in the active site of CYP51 of Candida albicans showed that lead compound specifically interacted with the amino acids residues in the active site, without binding with the heme of CYP51, which was different from azole antifungal drugs. The present study might afford a novel lead molecule to develop non-azole CYP51 inhibitors of fungi.

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Synthesis of both epimeric triacid ananlogs of kainic acid

Hai Ling Hao, Pi Sun, Guang Xing Wang, Kyoji Fruta, Masaaki Suzuki

中国化学快报. 2008, 19(03): 269-272. https://doi.org/10.1016/j.cclet.2008.01.003

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A practical and cheap method for synthesis of C-4 carboxylic acid substituted kainic acid analogue 5 and its epimer 6 from trans-4-hydroxyproline is described. Using this method, more interesting intermediates and analogues could be obtained easily.

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Synthesis of di-μ-oxo-tetra-(α-pentyloxy) tin(IV) phthalocyanine

Yi Ru Peng, Yu Hong Cao, Pei Feng Chen, Xiao Xia Huang

中国化学快报. 2008, 19(03): 273-276. https://doi.org/10.1016/j.cclet.2007.12.020

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Axially substituted tin phthalocyanines, namely dichloride-tetra-(α-pentyloxy) tin (IV) phthalocyanine 2, dihydroxy-tetra-(α-pentyloxy) tin (IV) phthalocyanine 3 and its dimmer di-μ-oxo-tetra-(α-pentyloxy) tin (IV) phthalocyanine 4 were synthesized. The catalytic effect of H₂O-free CaCl₂ in quinoline was used for condensation of dihydroxy tin phthalocyanine 3 to the cofacially arraydimmer 4. Their structures were characterized by UV-vis, IR, elemental analysis, MS, as well as ¹HNMR spectroscopy.

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Synthesis and thermal stability of a novel phosphorus-nitrogen containing intumescent flame retardant

Zhi Yu Ju, Yong Ye, Ru Yi Zou, Xin Cheng Liao, Yu Fen Zhao

中国化学快报. 2008, 19(03): 277-278. https://doi.org/10.1016/j.cclet.2007.12.022

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A novel phosphorus-nitrogen containing intumescent flame retardant (P-N IFR) was prepared via the reaction of dichloropentate with N-methylaniline. The structure of the product was confirmed by ¹H NMR, ³¹P NMR, MS and IR. TGA analysis showed it has effective thermal stability.

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New method in synthesizing an optical active intermediate for (R,R)-formoterol

Wei Fan, Lei Chen, Li Hai, Yong Wu

中国化学快报. 2008, 19(03): 279-280. https://doi.org/10.1016/j.cclet.2008.01.012

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(R)-1-(4-Methoxyphenyl) propan-2-amine 2a, an optical active intermediate for (R,R)-formoterol, was synthesized from D-alanine in 65% overall yield by using a simple route, which contained protecting amino group, cyclization, coupling with Grignard reagent, reduction and deprotection.

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Synthesis and cytotoxic activity of novel curcumin analogues

Qin Zhang, Yao Fu, Hao Wei Wang, Tao Gong, Yong Qin, Zhi Rong Zhang

中国化学快报. 2008, 19(03): 281-285. https://doi.org/10.1016/j.cclet.2007.12.035

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Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their cytotoxic activities against six tumor cell lines were tested by the standard MTT assay in vitro. The results indicated that four analogues (1A-1C, 1E) with solubilizing moieties showed selective potent cytotoxicity against HepG2, HeLa and CT26 cell lines, and analogue 1A and 1C exhibited more potent cytotoxicity than curcumin against CT26 cell line. It was suggested that introduction of appropriate substituents to 4-position of phenyl group might be a potential option for structural modification of curcumin.

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Dimethyl carbonate synthesis via transesterification catalyzed by quaternary ammonium salt functionalized chitosan

Yuan Zhao, Liang Nian He, Yuan Yi Zhuang, Jin Quan Wang

中国化学快报. 2008, 19(03): 286-290. https://doi.org/10.1016/j.cclet.2007.12.033

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A quaternary ammonium salt covalently linked to chitosan was first used as a catalyst for dimethyl carbonate (DMC) synthesis by the transesterification of propylene carbonate (PC) with methanol. The effects of various reaction variables like reaction time, temperature and pressure on the catalytic performance were also investigated. 54% DMC yield and 71% PC conversion were obtained under the optimal reaction conditions. Notably, the catalyst was able to be reused with retention of high catalytic activity and selectivity. Consequently, the process presented here has great potential for industrial application due to its advantages such as stability, easy preparation from renewable biopolymer, and simple separation from products.

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Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT_1A/SSRI activities

Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, Xue Qin Zhou

中国化学快报. 2008, 19(03): 291-294. https://doi.org/10.1016/j.cclet.2008.01.015

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The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5-HT_1A/SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5-HT_1A affinity. Compound 13a shows moderate dual activities and is a promising lead compound for further structure-activity relationships studies.

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N-(2-(2-Methoxyphenylthio)benzyl)-2-aryloxyethylamines: Synthesis and evaluation for dual 5-HT_1A/SSRI activities

Xue Dan Wu, Dong Zhi Liu, Ai Jun Li, Xue Qin Zhou

中国化学快报. 2008, 19(03): 295-298. https://doi.org/10.1016/j.cclet.2008.01.016

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The design, synthesis and biological evaluation of N-(2-(2-methoxyphenylthio) benzyl)-2-aryloxyethyl amines with dual 5-HT_1A/SSRI activities are reported. Compound 8e displays the best dual activities and is a promising lead compound for further SAR studies.

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One new bufadienolide biotransformed from cinobufagin by Cunninghamella elegans

Li Qiao, Yu Zhi Zhou, Huan Chen, Jia Qing Cao, Yue Hu Pei

中国化学快报. 2008, 19(03): 299-301. https://doi.org/10.1016/j.cclet.2007.12.019

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Cunninghamella elegans has been employed for the biotransformation of cinobufagin (1) to afford one metabolites. The structure of the transformation product has been characterized as 7β, 12β-dihydroxylcinobufagin (2). Product 2 is a new compound. In vitro cytotoxic activities of the biotransformation product and the substrate-cinobufagin have been assayed against HeLa; they all showed cytotoxic activities.

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Alkaloids from the root barks of Goniothalamus cheliensis

Miao Miao Jiang, Xue Zhang, Yi Dai, Hao Gao, Hong Wei Liu, Nai Li Wang, Wen Cai Ye, Xin Sheng Yao

中国化学快报. 2008, 19(03): 302-304. https://doi.org/10.1016/j.cclet.2008.01.007

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(3S)-2-Oxo-5, 12-dimethoxy-3-hydroxy-3-methylbenz[f]indoline (1), a new benzoxindole alkaloid, along with two known alkaloids, was isolated from the root barks of Goniothalamus cheliensis Hu. The structure was elucidated by spectroscopic evidences, and the absolute configuration was determined by CD spectrum.

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A new triterpenoid saponin from Anemone raddeana

Fu Li, Li Sheng Ding, Ming Kui Wang

中国化学快报. 2008, 19(03): 305-307. https://doi.org/10.1016/j.cclet.2007.12.034

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A new triterpenoid bisglycoside, named raddeanoside R₁₉, was isolated from the roots of Anemone raddeana. Its structure was elucidated on the basis of ESI-MS, ¹³C NMR, and chemical methods.

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A new benzylisoquinoline alkaloid from stems of Nelumbo nucifera

Xu Hong Duan, Jian Qin Jiang

中国化学快报. 2008, 19(03): 308-310. https://doi.org/10.1016/j.cclet.2008.01.013

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A new benzylisoquinoline alkaloid, named nelumstemine (1), 1-(4'-hydroxybenzoyl)-6, 7-dimethoxy-3, 4-dihydroisoquinoline, was isolated from the stems of Nelumbo nucifera Geartn. Its structure was established on the basis of spectral analysis.

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The setereoselective preparation of β-keto esters using baker's yeast in the presence of rice wine koji

Jin Cui, Ming Jie Zhang, Xiang Qian Wang, Nai Jing Cui

中国化学快报. 2008, 19(03): 311-313. https://doi.org/10.1016/j.cclet.2008.01.005

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By the addition of rice wine koji, enhancement of the reactivity was observed for the baker's yeast reduction of b-keto esters into (S)-β-hydroxy esters with high enantiomeric purity (73-98%).

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Hydrogen peroxide biosensor based on electrodeposition of zinc oxide nanoflowers onto carbon nanotubes film electrode

Hui Ping Bai, Xu Xiao Lu, Guang Ming Yang, Yun Hui Yang

中国化学快报. 2008, 19(03): 314-318. https://doi.org/10.1016/j.cclet.2007.12.030

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A new amperometric biosensor for hydrogen peroxide was developed based on adsorption of horseradish peroxidase at the glassy carbon electrode modified with zinc oxide nanoflowers produced by electrodeposition onto multi-walled carbon nanotubes (MWNTs) film. The morphology of the MWNTs/nano-ZnO electrode has been investigated by scanning electron microscopy (SEM), and the electrochemical performance of the electrode has also been studied by amperometric method. The resulting electrode offered an excellent detection for hydrogen peroxide at -0.11 V with a linear response range of 9.9×10^-7 to 2.9×10^-3 mol/L with a correlation coefficient of 0.991, and response time < 5 s. The biosensor displays rapid response and expanded linear response range, and excellent stability.

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Electrochemical oxidation behavior of hydroxypivalaldehyde in the ionic liquids

Jian Fang Zhong, De Liang He, Zhou Zhou, Yi Bin Xu

中国化学快报. 2008, 19(03): 319-323. https://doi.org/10.1016/j.cclet.2007.12.017

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The similar electrochemical oxidation behaviors of hydroxypivalaldehyde in ionic liquids (ILs) medium, C₄MIMPF₆, C₄MIMBF₄ and C₈MIMPF₆, are investigated using classic electrochemical methods, respectively. Only the product, hydroxypivalic acid is detected by high performance liquid chromatography (HPLC). It can be conferred that the electrochemical oxidation of hydroxypivalaldehyde consists of two successive one-electron irreversible reactions at glass carbon (GC) electrode and the possible reaction mechanism in the ILs is proposed firstly. The diffusion coefficients of hydroxypivalaldehyde are obtained according to the electrochemical characteristics of hydroxypivalaldehyde in C₄MIMPF₆, C₄MIMBF₄ and C₈MIMPF₆.

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Study of electrospray ionization tandem mass spectrometry of the benzofuranone compounds

Zhan Qi Niu, Yu Min Sun, Feng Niu, Jian Han, Da Wei Chen

中国化学快报. 2008, 19(03): 324-328. https://doi.org/10.1016/j.cclet.2007.12.008

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A detailed analysis of benzofuranone compounds under multiple tandem mass spectrometry (ESI-MSⁿ) conditions is reported. Element composition data of the fragment ions were obtained with the aid of comparison of the multiple tandem mass spectra of four compounds, and the structures of which are identical except for some substituted groups or epimers or cis-trans-isomers. Attempts have been made to provide rational pathways for the formation of the fragment ions from these protonated compounds. And the structure-fragmentation relationships will facilitate the characterization of the structures of other analogs.

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Simultaneous determination of seven flavonoids in Epimedium by liquid chromatography-tandem mass spectrometry method

Cai Sheng Wu, Bao Lin Guo, Yu Xin Sheng, Jin Lan Zhang

中国化学快报. 2008, 19(03): 329-332. https://doi.org/10.1016/j.cclet.2008.01.018

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In this paper, a sensitive and specific liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS) method has been developed and validated for the identification and determination of seven flavonoids, namely epimedin A, epimedin B, epimedin C, icariin, sagittatoside B, 2"-O-rhamnosyl icariside II, and baohuoside I in Epimedium from different sources.

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Rhus laccase catalysis and product characterization of 1,2-dimethoxyphenol in organic solutions

Yun Yang Wan, Yu Min Du, Tetsuo Miyakoshi

中国化学快报. 2008, 19(03): 333-336. https://doi.org/10.1016/j.cclet.2007.12.021

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Dimethoxyphenol was a widely used substrate in determination of laccases activity. It was surprised, however, that the products of it had not been completely determined until now. Studies were thus conducted on Rhus laccase (RL) and immobilized Rhus laccase (IRL)-catalyzed oxidation of 2, 6-dimethoxyphenol (DMP) in water-organic solvent systems. Only one product, 3, 3', 5, 5'-tetramethoxy-1, 1'-biphenyl-4, 4'-diol (TMBP), was produced by RL catalysis, and it was thoroughly characterized by FT-IR, NMR and GC-MS, etc.

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Synthesis and electrochemical properties of Li_1-xV_xCr_yFe_1-yPO₄/C as a cathode material

Shi Tao Song, Pei Hua Ma, Shi You Li, Xiao Chuan Deng, Chun Yan Yan

中国化学快报. 2008, 19(03): 338-341. https://doi.org/10.1016/j.cclet.2008.01.001

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Composites Li_1-xV_xCr_yFe_1-yPO₄/C (x=0.01, 0.02; y=0.01, 0.02) were synthesized by solid-state reaction method. The influence of the content of doping vanadium and chromium on the structure of Li_1-xV_xCr_yFe_1-yPO₄/C was investigated by XRD, while the morphology of powders was observed by SEM. The investigation of the electrochemical performances showed that the Li_0.99V_0.01Cr_0.02Fe_0.98PO₄/C material has a higher capacity. At 0.1 C discharging rate, it is capable of delivering reversible specific capacity of 163.8 mAh/g with fairly stable cycleability.

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Synthesis and DNA cleavage activity of diiron(III) complex bearing pyrene group

Xiao Qiang Chen, Jing Yun Wang, Tong Yan Zhang, Li Zhu Zhang, Xiao Jun Peng

中国化学快报. 2008, 19(03): 342-344. https://doi.org/10.1016/j.cclet.2007.12.028

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As DNA cleavage agent, a new diiron (III) complex (Fe₂L_b), in which a DNA-intercalator (pyrene) is covalently linked to a diferric moiety, has been synthesized and characterized. The DNA-binding property and DNA cleavage activity of the complex have also been investigated.

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LiFePO₄ doped with magnesium prepared by hydrothermal reaction in glucose solution

Xiu Qin Ou, Guang Chuan Liang, Jin Sheng Liang, Sheng Zhao Xu, Xia Zhao

中国化学快报. 2008, 19(03): 345-349. https://doi.org/10.1016/j.cclet.2007.10.052

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Lithium iron phosphate (LiFePO₄) doped with magnesium was hydrothermally synthesized from commercial LiOH, FeSO₄, H₃PO₄ and MgSO₄ with glucose as carbon precursor in aqueous solution. The samples were characterized by X-ray powder diffraction, scanning electron microscopy and constant charge-discharge cycling.The results show that the synthesized powders have been in situ coated with carbon precursor produced from caramel reaction of glucose. At ambient temperature (28±2℃), the electrochemical performances of LiFePO₄ prepared exhibit the high discharge capacity of 135 mAh g^-1 at 5C and good capacity retention of 98% over 90 cycles. The excellent electrochemical performances should be correlated with the intimate contact between carbon and LiFePO₄ primary and secondary particles, resulting from the in situ formation of carbon precursor/carbon, leading to the increase in conductivity of LiFePO₄.

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A mechanistic study of flame retardance of novel copolyester phosphorus containing linked pendant groups by TG/XPS/direct Py-MS

Nian Hua Huang, Qiang Zhang, Chou Fan, Jian Qi Wang

中国化学快报. 2008, 19(03): 350-354. https://doi.org/10.1016/j.cclet.2007.11.021

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The flame retardant mechanism of the copolyester phosphorus containing linked pendant groups was investigated by thermogravimetric (TG), X-ray photoelectron spectroscopy (XPS) and direct insertion probe pyrolysis mass spectrometry (DPMS) technique. TG results show that the incorporation of phosphorus containing unit linked pendant groups can destabilize the copolyester due to the cleavage of P-CH₂ bond, and phosphorus containing units cannot promote the char-formation of the copolyester during the thermal degradation of the copolyester. XPS spectra indicate that with the increase of the temperature, the P-CH₂ bonds of the copolyester break down gradually, the concentration of phosphorus in the condensed phase products decrease gradually and the chemical state of phosphorus does not change in the temperature of 250-380℃. Direct pyrolysis MS suggests that the P-CH₂ bonds cleavage occurs at pendant groups and species containing phosphorus can volatilize into the gas phase. A flame retardant mechanism is proposed for the gas phase mode of action of the halogen-free copolyester phosphorus containing linked pendant groups.

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Synthesis and characteristic of double hydrophilic block copolymer with amine pendant chains

Yue Jun Zhu, Ye Bang Tan, Xu Du, Ji Cheng Piao, Qi Feng Zhou

中国化学快报. 2008, 19(03): 355-358. https://doi.org/10.1016/j.cclet.2008.01.008

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Novel double hydrophilic block copolymers with amine pendant chains were synthesized by polymerization of 4-vinyl benzylamine hydrochloric salt using 4, 4'-azo-bis[4-cyanopentanoate poly (ethylene glycol) ester] as macroazoinitiator. The structures of the copolymers were characterized by ¹H NMR, FTIR spectra and acid-base titration, GPC-MALS techniques.

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Synthesis of novel aromatic polyimides containing bulky side chain for vertical alignment liquid crystals

Jian Wang, Ying Han Wang

中国化学快报. 2008, 19(03): 359-362. https://doi.org/10.1016/j.cclet.2007.12.032

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In this study, a novel 4-(4-octyloxybenzoyloxy) biphenyl-3', 5'-diaminobenzoate and polyimides based on it were synthesized.The polyimide with mesogenic unit side chain exhibited excellent vertical alignment for nematic liquid crystal (LC). The pretilt angles of LCs above 89° were kept after the rubbing process with 220 mm rubbing strength. The polyimide films as the alignment layer were baked at 120℃ for 12 h, the vertical alignment of LCs was still uniform and stable. Meanwhile, the UV-vis spectra of the novel polyimide films showed the high transparency in a visible wave length.

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The copolymerization of L-lactide and ε-caprolactone using magnesium octoate as a catalyst

Zhi Yong Wei, Lian Liu, Jun Gao, Pei Wang, Min Qi

中国化学快报. 2008, 19(03): 363-366. https://doi.org/10.1016/j.cclet.2008.01.004

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Copolymerizations of L-lactide (L-LA) and e-caprolactone (ε-CL) were conducted in bulk using magnesium octoate as a catalyst. The reactivity ratios of L-LA and ε-CL were determined to be r_L=23 and r_C=0.22, respectively. The sequence analyses of the copolymers were performed on ¹³C NMR. An increase in the reaction temperature enhances the role of transesterification and the extent of randomness.

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Hydrophobic modification of poly(phthalazinone ether sulfone ketone) hollow fiber membrane for vacuum membrane distillation

Zhao Jin, Da Ling Yang, Shou Hai Zhang, Xi Gao Jian

中国化学快报. 2008, 19(03): 367-370. https://doi.org/10.1016/j.cclet.2007.12.029

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New hydrophobic poly (phthalazinone ether sulfone ketone) (PPESK) hollow fiber composite membranes were obtained by surface-coated modification method.

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Photochemical degradation of environmentally persistent perfluorooctanoic acid (PFOA) in the presence of Fe(III)

Yuan Wang, Peng Yi Zhang, Gang Pan, Hao Chen

中国化学快报. 2008, 19(03): 371-374. https://doi.org/10.1016/j.cclet.2007.11.007

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Environmentally persistent and bioaccumulative perfluorooctanic acid (PFOA) was difficult to be decomposed under the irradiation of 254 nm UV light. However, in the presence of 80 μmol/L Fe (III), 80%of PFOAwith initial concentration of 48 μmol/L (20 mg/L) was effectively degraded and 47.8% of fluorine atoms in PFOA molecule were transformed into inorganic fluoride ion after 4 h reaction. Shorter chain perfluorocarboxylic acids bearing C₃-C₇ and fluoride ion were detected and identified by LC/MS and IC as the degradation products in the aqueous solution. It was proposed that complexes of PFOA with Fe (III) initiated degradation of PFOA irradiated with 254 nm UV light.

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DFT study on mechanism of the classical Biginelli reaction

Jin Guang Ma, Ji Ming Zhang, Hai Hui Jiang, Wan Yong Ma, Jian Hua Zhou

中国化学快报. 2008, 19(03): 375-378. https://doi.org/10.1016/j.cclet.2007.11.030

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The condensation of benzaldehyde, urea, and ethyl acetoacetate according to the procedure described by Biginelli was investigated at the B3LYP/6-31G (d), B3LYP/6-31+G (d, p), and B3LYP/6-311+G (3df, 2p)//B3LYP/6-31+G (d, p) levels to explore the reaction mechanism. According to the mechanism proposed by Kappe, structures of five intermediates were optimized and four transition states were found. The calculation results proved that the mechanism proposed by Kappe is right.

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2008年, 第19卷, 第03期　刊出日期：2008-03-20

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2008年, 第19卷, 第03期 刊出日期：2008-03-20

2008年, 第19卷, 第03期　刊出日期：2008-03-20