A temperature-regulated bioorthogonal reaction to target lysine: Hemiacetal pharmacophore in genipin irreversibly binds with UCP2, inhibiting mitochondrial thermogenesis

A temperature-regulated bioorthogonal reaction to target lysine: Hemiacetal pharmacophore in genipin irreversibly binds with UCP2, inhibiting mitochondrial thermogenesis

Fukui Shen, Wen Yang, Kaixue Zhang, Yanting Jiao, Jing Cui, Yuanyuan Hou, Gang Bai

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Chinese Chemical Letters ›› 2023, Vol. 34 ›› Issue (10) : 108203. DOI: 10.1016/j.cclet.2023.108203

A temperature-regulated bioorthogonal reaction to target lysine: Hemiacetal pharmacophore in genipin irreversibly binds with UCP2, inhibiting mitochondrial thermogenesis

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