Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A<sub>2A</sub> adenosine receptors and histone deacetylases

doi:10.1016/j.cclet.2023.108136

Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A_2A adenosine receptors and histone deacetylases

Ruiquan Liu, Wenwen Duan, Wenzhong Yan, Jinfeng Zhang, Jianjun Cheng

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Chinese Chemical Letters ›› 2024, Vol. 35 ›› Issue (01) : 108136. DOI: 10.1016/j.cclet.2023.108136

Communications

Design and synthesis of tri-substituted pyrimidine derivatives as bifunctional tumor immunotherapeutic agents targeting both A_2A adenosine receptors and histone deacetylases