Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3<em>H</em>)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

doi:10.1016/j.cclet.2020.09.035

Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Daxiong Li, Chunsheng Zhang, Wei Ding, Siming Huang, Le Yu, Nan Lu, Wenkai Pan, Yiming Li, Erik De Clercq, Christophe Pannecouque, Hongbing Zhang, Yueping Wang, Yanping He, Fener Chen

PDF(803 KB)

Chinese Chemical Letters ›› 2021, Vol. 32 ›› Issue (03) : 1020-1024. DOI: 10.1016/j.cclet.2020.09.035

Communications

Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors