Design, synthesis and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

Wei-Huang Zhou, Xi-Guo Xu, Jin Li, Xiao Min, Jian-Zhong Yao, Guo-Qiang Dong, Chun-Lin Zhuang, Zhen-Yuan Miao, Wan-Nian Zhang

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Chinese Chemical Letters ›› 2017, Vol. 28 ›› Issue (02) : 422-425. DOI: 10.1016/j.cclet.2016.09.001
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Design, synthesis and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

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