中国化学快报

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Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5

Xing Zhou Li, Xian Ping Dai, Kang Ying Lai, Li Li Wang, Zhi Bing Zheng, Song Li

中国化学快报. 2008, 19(04): 379-382. https://doi.org/10.1016/j.cclet.2008.01.032

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A series of 2, 4, 5-triaryl substituted 1H-pyrazol-3(2H)-ones, as ALK5 inhibitors, were desigened, synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1 μmol/L and displayed no significant cytotoxicities at 30 μmol/L.

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Formylation of N-arylpyrazole containing active amino group using Vilsmeier-Hacck reaction

Yi Luo, Ping Zhong, Xiao Hong Zhang, Qiu Lian Lin, Ye Na Chen

中国化学快报. 2008, 19(04): 383-386. https://doi.org/10.1016/j.cclet.2008.01.025

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Two species of N-arylpyrazoles containing active amino group were synthesized.And formylations of N-arylpyazoles containing amino in different position of pyrazole rings using Vilsmeier-Hacck reaction gave a series of useful pyrazole intermediates.The important features of this protocol were cheap materials, easy process, mild reaction conditions and good yield of products.

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Synthesis and NO production inhibition of novel Mannich base derivatives of irisolidone

Jiao Wang, Ying Zhong, Lu Liu, Xin Quan Ji, Zhi Guo Zhang

中国化学快报. 2008, 19(04): 387-389. https://doi.org/10.1016/j.cclet.2008.01.024

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Five new C-8 Mannich base derivatives of irisolidone 2a-2e were synthesized and their nitric oxide (NO) production inhibitory activity was evaluated.Compounds 2a, 2b, 2c and 2e displayed stronger activities in vitro than the parent compound irisolidone.

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Preparation of 2,6-diisopropylnaphthalene with recycled process of isomers

Zheng Hua Tian, Gui Li Zhao, Hong Min Jia, Ben Li, Wei Qi Hu

中国化学快报. 2008, 19(04): 390-394. https://doi.org/10.1016/j.cclet.2008.01.033

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2, 6-Diisopropylnaphthalene (2, 6-DIPN), as the precursor of important monomer 2, 6-naphthalene dicarboxylic acid, was prepared by hydroisopropylation of refined naphthalene with propene over shape-selective catalyst.Naphthalene conversion of 92% and 2, 6-DIPN selectivity of 64% were obtained.Static melt crystallization was applied to separate and purify 2, 6-DIPN from its isomers, resulted in a product purity of ≥99%.The other isomers were converted into monoisopropylnaphthalene, which also reacted with propcne to form 2, 6-DIPN.A recycled process including hydroisopropylation, separation and transalkylation was established, the yield of 2, 6-DIPN based on naphthalene could be doubled by one cycle operation.

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Synthesis of aliphatic amidediol and used as a novel mixed plasticizer for thermoplastic starch

Jian She Zhang, Jiu Gao Yu, Ying Wu, Xiao Fei Ma

中国化学快报. 2008, 19(04): 395-398. https://doi.org/10.1016/j.cclet.2007.12.024

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In this paper, aliphatic amidediol was synthesized and mixed with glycerol used as a plasticizer for preparing thermoplastic starch (AGPTPS).The yield of aliphatic amidediol was 91%.FT-IR expressed that the mixture of aliphatic amidediol and glycerol formed stronger and stable hydrogen bond with starch molecules compared to the native cornstarch.By scanning electron microscope (SEM) native cornstarch granules were proved to transfer to a homogeneous continuous system.After being stored for a period time at room temperature, the mechanical properties of AGPTPS were also studied.As a mixed plasticizer, aliphatic amidediol and glycerol would be practical to extend TPS application scopes.

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D301 resin as a solid base for phosphine-free Heck reactions with heteroaryl halides

Wen Pei, Xiang Mei Wu

中国化学快报. 2008, 19(04): 399-402. https://doi.org/10.1016/j.cclet.2008.01.034

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A new and practical method of the D301 resin, a weak basic anion exchange resin with secondary amine functionality (Grade Matrix Structure:Styrene-DVB D301R), used as base to Heck reactions catalyzed by palladium reagent without phosphine compound as ligand is described.It was found that the D301 resin used as base is an efficient and reusable base and can be regenerated and recycled in the reaction.The olefination of heteroaryl halides prepared the corresponding products in good yields using D301 resin as base.

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Synthesis of macrocyclic lactones with methoxysulfonyl side chain

Chuan Jin Hou, Xiao Mei Liang, Jing Ping Wu, Dao Quan Wang

中国化学快报. 2008, 19(04): 403-405. https://doi.org/10.1016/j.cclet.2008.01.039

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Two representative macrocyclic lactones with methoxysulfonyl side chain (5a and 5b) were synthesized employing Michael addition with acrolein and ring enlargement as the key steps, starting from potassium α-oxocycloalkylsulfonates (1) in total yields of 45 and 57%, respectively.

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Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide

Wei Guo, Lv Yin Zheng, Yong Quan Wu, Xiao Lin Fan

中国化学快报. 2008, 19(04): 406-408. https://doi.org/10.1016/j.cclet.2008.01.014

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A serial of novel cercaricides that can self-diffuse on the water surface were designed and synthesized according to the special habit of cercariae larvae.These compounds were derived from niphensamide.While the compounds were dropped on the surface of water, the liquor diffused along the air-water interface and formed thin membranes floating on the water surface immediately.The strong cercaricidal activities against the cercariae larvae of Schistosome japonicum of these compounds have been revealed by further experiments.

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Synthesis of novel 15-membered macrolide derivatives

Rui Qing Xian, Shu Tao Ma, Bo Jiao

中国化学快报. 2008, 19(04): 409-411. https://doi.org/10.1016/j.cclet.2008.01.040

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In order to develop new antibiotics effective against resistant bacteria, a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11, C-12 and C-4" positions.Their structures were confirmed by MS, IR, ¹H NMR or ¹³C NMR.

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New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]thiophen-3-yl)-2-methylpropanol derivatives: Synthesis and evaluation for dual 5-HT_1A/SSRI activities

Ai Jun Li, Xiao Hua Zhang, Xue Qin Zhou, Dong Zhi Liu

中国化学快报. 2008, 19(04): 412-414. https://doi.org/10.1016/j.cclet.2008.01.017

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A series of 3-(4-arylpiperazin-1-yl)-l-(benzo[b]thiopben-3-yl)-2-methylpropanol derivatives were designed and synthesized based on 5-HT_1A/SSRI drugs design strategies.The synthesized compounds were evaluated for their dual 5-HT_1A/5-HTT activities.

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Synthesis of α-D-GlcpNAc-(1→2)-[α-D-ManpNAc-(1→3)-]α-L-Rhap-(1→2)-α-L-Rhap-(1→3)-α-L-Rhap,the repeating unit of O10 antigen from Acinetobacter baumannii

Jian Jun Zhang, Guang Hui Zong, Xiao Mei Liang, Yun Qi Li, Dao Quan Wang, Fan Zuo Kong

中国化学快报. 2008, 19(04): 415-418. https://doi.org/10.1016/j.cclet.2008.01.028

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An efficient synthesis of α-D-GlcpNAc-(1→2)-[α-D-ManpNAc-(1→3)-]α-L-Rhap-(1→2)-α-L-Rhap-(1→3)-α-L-Rhap (1), the repeating unit of the O10 antigen from Acinetobacter baumannii was achieved via sequential assembly of the building blocks, p-methoxylphenyl 2, 4-di-O-benzoyl-α-L-rhamnopyranoside (2);2-O-allyloxycarbonyl-3, 4-di-O-benzoyl-α-L-rhanmopyranosyl trichloroacetimidate (3);4-methoxylphenyl 3-O-allyloxycarbonyl-4-O-benzoyl-α-L-rhamnopyranoside (4);2-azido-3-O-benzoyl-2-deoxy-4, 6-O-isopropylidene-α-D-mannopyranosyl trichloroacetimidate (5);2-azido-3, 4, 6-tri-O-benzoyl-2-deoxy-α, β-D-glucopyrano syl trichloroacetimidate (6).The total yield of 1 from 4 was 4.7%.

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Synthesis of phenol-class azo derivatives of 4-aminosalicylic acid

Shi Fei Sheng, Hui Xia Zheng, Jiang Liu, Zheng Bao Zhao

中国化学快报. 2008, 19(04): 419-422. https://doi.org/10.1016/j.cclet.2008.01.042

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To explore the better prodrug of 4-aminosalicylic acid (4-ASA) with higher activity and less side effects against the inflammatory bowel disease.4-ASA, after a succession of synthesis process, was conjugated with various carrier molecules to get seven azo derivatives of 4-ASA.All compounds were characterized by FT-IR, ¹H NMR, ¹³C NMR spectras in detail.New derivatives of 4-ASA were definituded.

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Solvent-free synthesis of some new 2-(3,5-dimethoxy-4-methylpheyl)-5-aryl-1,3,4-oxadiazoles

Aamer Saeed, Amara Mumtaz

中国化学快报. 2008, 19(04): 423-427. https://doi.org/10.1016/j.cclet.2008.02.001

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An expeditious microwave-accelerated one-step synthesis of some new 2-(3, 5-dimethoxy-4-methylphenyl)-5-aryl-1, 3, 4-oxadiazoles by reaction of 3, 5-dimethoxy-4-methyl hydrazide with different carboxylic acids in presence of thionyl chloride under neat conditions, has been achieved.

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Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity

Yao Liu, Jing Su, Jun Hai Xiao, Shi Bo Jiang, Hong Lu, Wu Zhong, Li Li Wang, Xiao Hong Yang, Song Li

中国化学快报. 2008, 19(04): 428-430. https://doi.org/10.1016/j.cclet.2008.01.029

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A series of novel benzocycloheptene derivatives have been synthesized.Their structures were confirmed by MS and ¹H-NMR.These compounds exhibited potent anti-HIV-1 activities.

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A pure blue light emitting binaphthyl derivative: Synthesis and properties

Qing Guo He, Zeng Ze Chu, Gang Tie Lei, An Jun Qin, Hong Zhen Lin, Feng Lian Bai, Jian Gong Cheng, Yong Qiu

中国化学快报. 2008, 19(04): 431-434. https://doi.org/10.1016/j.cclet.2008.02.002

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A binaphthyl derivative with pyrene on 3 and 3' positions was synthesized and characterized via Suzuki coupling reaction.Emission maximum in solution was located at 390 nm with a quantum efficiency of 68% by taking 9, 10-diphenyl anthracene as reference, while it is shifted to 450 nm with FWHM of 104 nm resulting from aggregation state in solid film.Glass transition temperature (T_g) and decomposition temperature were measured to be 184 and 447℃, respectively, by DSC and TGA.Unlike its photoluminescence spectrum, electroluminescent spectrum peaked at about 460 nm and shows a FWHM of 69 nm corresponding to a pure blue emission.The turn-on voltage, luminance and efficiency maximum were 5 V, 2953 cd/m² and 1.37 cd/A with CIE color coordinate of (0.16, 0.15), in the device structure of ITO/NPB (40 nm)/PY-BN-PY (15 nm)/BPhen (40 nm)/Mg:Ag.

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Synthesis and study of MPNS/SMA nano-composite tanning agent

Hui Pan, Mei Qi, Zhi Jun Zhang

中国化学快报. 2008, 19(04): 435-437. https://doi.org/10.1016/j.cclet.2008.01.011

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The radical polymerization of maleic anhydride (MA), styrene (ST) with the vinyl groups introduced onto the surface of the nano-sized silica via solution polymerization method was developed.The methacryloxypropyl nano-sized silica (MPNS) was used as macromonomer and polymerized with maleic anhydride and styrene by initiating with BPO in toluene.The structure and properties of MPNS/SMA nano-composite were characterized by FT-IR spectra and TEM.Meanwhile, it was applied as tanning agent compared with the traditional styrene-maleic anhydride copolymer in leather.It was found that the applied leather had better quality characteristics with the addition of the nano-sized silica.

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A new triterpenoid from Alisma orientalis

Xue Yan Hu, Yuan Qiang Guo, Wen Yuan Gao, Hai Xia Chen, Tie Jun Zhang

中国化学快报. 2008, 19(04): 438-440. https://doi.org/10.1016/j.cclet.2008.01.019

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A new triterpenoid, named 11, 25-anhydro-alisol F, was isolated from the rhizomes of Alisma orientalis together with nine known compounds.Their structures were elucidated by spectroscopic methods.Some compounds showed weak anti-tumor activities in eytotoxic experiments.

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New ent-kaurane-type diterpenoids from Isodon nervosus

Fu Lin Yan, Lan Qing Guo, Ji Xia Zhang, Su Ping Bai, Han Dong Sun

中国化学快报. 2008, 19(04): 441-443. https://doi.org/10.1016/j.cclet.2008.01.006

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Two new ent-kaurane-type diterpenoids, 6β, 7β, 13α-trihydroxy-1α-acetoxy-7α, 20-epoxy-ent-kaur-16-en-15-one (1) and 15β-hydroxy-6, 7-seco-6, 11β:6, 20-diepoxy-1α, 7-olide-ent-kaur-16-ene (2) were isolated from the Isodon nervosus, and the structures were elucidated by spectroscopic analysis.

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A new C₂₁ steroid glycoside from Marsdenia tenacissima

Jing Liu, Zhi Bin Yu, Yun Hua Ye, Ya Wei Zhou

中国化学快报. 2008, 19(04): 444-446. https://doi.org/10.1016/j.cclet.2008.01.021

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A new C₂₁ steroid glycoside, 11a-O-tigloyl-12-β-O-acetyl tenacigenin B 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyr-anosyl-(1→4)-3-O-methyl-6-deoxy-β-D-allopyranosyl-(1→4)-β-D-oleandropyranoside (1), named tenacissoside N was isolated from the stems of Marsdenia tenacissima.The structure of the glycoside was identified by HR-ESI-MS and NMR spectra.

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A new phenolic compound from Crinum asiaticum L.

Qian Sun, Wei Dong Zhang, Yun Heng Shen, Chuan Zhang, Hui Liang Li

中国化学快报. 2008, 19(04): 447-449. https://doi.org/10.1016/j.cclet.2008.01.022

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A new phenolic compound was isolated from the ethanol extract of the bulbs of Crinum asiaticum L.var.sinicum Baker.Its structure was defined as 1-(2-hydroxy-4-hydroxymethyl) phenyl-6-O-caffeoyl-β-D-gluco-pyranoside on the basis of spectroscopic evidences.

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A new iridoid glycoside from Veronica sibirica

Jie Teng, Fu Geng Zhang, Yan Wen Zhang, Yoshihisa Takaishi, Hong Quan Duan

中国化学快报. 2008, 19(04): 450-452. https://doi.org/10.1016/j.cclet.2008.01.035

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A new iridoid glycoside, versibirioside (1), and a known iridoid glycoside, verbaspinoside (2), were isolated from the whole plant of Veronica sibirica L.Their structures were elucidated by spectroscopic methods, including 2D-NMR spectra.

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Immunosuppressive terpenoids from Tripterygium wilfordii

Qian Shen, ZhiYao, Yoshihisa Takaishi, Yan Wen Zhang, Hong Quan Duan

中国化学快报. 2008, 19(04): 453-456. https://doi.org/10.1016/j.cclet.2008.01.031

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Two new terpenes, triptobenzene P (1) and wilforone (2) were isolated from Tripterygium wilfordii, as well as 10 known terpenes.Their structures were elucidated by spectroscopic methods.Compounds 2-4, 8, 10, and 11 showed significantimmunosuppressive activities.

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Two triterpene glycosides from the sea cucumber Bohadschia marmorata Jaeger

Wei Hua Yuan, Yang Hua Yi, Ling Li, Bao Shu Liu, Hong Wei Zhang, Peng Sun

中国化学快报. 2008, 19(04): 457-460. https://doi.org/10.1016/j.cclet.2008.01.026

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Further studies on the sea cucumber Bohadschia marmorata Jaeger led to the isolation of a new holostan-type triterpene glycoside, Marmoroside C (1) together with a known triterpene glycoside (2).On the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions, the structure of the new triterpene glycoside was elucidated as 3-0-[3-O-methyl-β-D-glucopyranosyl-(1→3)-13-D-glucopyranosyl-(1→4)-β-D-quinovopyranosyl-(1→2)-4-O-sodium-sulfato-β-D-xylo-pyranosyl]-25-acetoxy-22-oxo-9(11)-holostene-3β, 12α, 17α-triol.

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Two new furostanol saponins from the seeds of Allium cepa L.

Ling Yuan, Teng Fei Ji, Ai Guo Wang, Jian Bo Yang, Ya Lun Su

中国化学快报. 2008, 19(04): 461-464. https://doi.org/10.1016/j.cclet.2008.02.005

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Phytochemical analysis of the n-BuOH extract from the seeds of Allium cepa L.led to isolation of four furostanol saponins, two of which were new compounds, named ceparoside A (1a) and ceparoside B (2a).The chemical structures of the new compounds were elucidated through a combination of NMR, MS spectral data and chemical analysis.

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Determination of trace amounts of morphine in human plasma by anodic adsorptive stripping differential pulse voltammetry

Ali Niazi, Ateesa Yazdanipour

中国化学快报. 2008, 19(04): 465-468. https://doi.org/10.1016/j.cclet.2007.12.036

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New adsorptive anodic differential pulse stripping voltammetry method for the direct determination of morphine at trace levels in human plasma of addicts is proposed.The procedure involves an adsorptive accumulation of morphine on a HMDE, followed by oxidation of adsorbed morphine by voltammetry scan using differential pulse modulation.The optimum conditions for the analysis of morphine are pH 10.5, E_acc of-100 mV (vs.Ag/AgCl), and t_acc of 120 s.The peak current is proportional to the concentration of morphine, and a linear calibration graph is obtained at 0.01-3.10 μg mL^-1.A relative standard deviation of 1.06% (n=5) was obtained, and the limit of detection was 3 ng mL^-1.The capability of the method for the analysis of real samples was evaluated by the determination of morphine in spiked human plasma and addicts human plasma with satisfactory results.

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Chemical inequivalence behavior of the protons attached to the same carbon in ethylene-propylene copolymer (EPC)

Peng Yu Bi, Hui Ru Dong, Nan Nan Wang

中国化学快报. 2008, 19(04): 469-474. https://doi.org/10.1016/j.cclet.2007.12.037

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Six ethylene-propylene copolymer samples with different structural parameters were analyzed by ¹H NMR, ¹³C NMR and ¹H-¹³C COSY in this paper.With the aid of the ¹H-¹³C COSY spectra of ethylene-propylene copolymer, the chemical inequivalence behavior of the protons attached to the same carbon in the ethylene-propylene copolymer could be observed.Four basic types of chemical bonds were divided, and two kinds of main conformations were proposed to explain this phenomenon.Based on the calculation of conformation distribution, it can be proved that the explanation of this phenomenon was reasonable.

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Methane formation from CaCO₃ reduction catalyzed by high pressure

Jin Yang Chen, Lu Jiang Jin, Jun Ping Dong, Hai Fei Zheng, Gui Yang Liu

中国化学快报. 2008, 19(04): 475-478. https://doi.org/10.1016/j.cclet.2008.01.023

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Under high pressures of several giga-pascals using hydrothermal diamond anvil cell, methane generated directly from CaCO₃ reduction in gold-lined chamber is in situ measured by Raman spectroscopy at the temperature of 550℃.The reducing agents include FeO, SiO and natural fayalite (Fe₂SiO₄), and the resource of hydrogen are water and natural serpentine (Mg₃Si₂O₅(OH)₄).The study demonstrates the existence of abiogenic formation of methane under high pressures in the Earth's interior and that the application of high pressure to catalyze multicomponent reactions is a very promising method.

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Synthesis and characterization of new fluorescent nanoparticles

Liang Tao, Xu Hun, Zhu Jun Zhang

中国化学快报. 2008, 19(04): 479-482. https://doi.org/10.1016/j.cclet.2008.01.002

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A novel kind of fluorescent nanoparticles (FNPs) has been prepared using a precipitation polymerization method.Methacrylic acid, trimethylolpropane trimethacrylate and azobisisobutyronitrile were used as functional-monomer, cross-linker and initiator, respectively.Compared with other fluorescent nanoparticles, the FNPs have the characteristics including low dye leakage and good photostability.The fluorescence microscopy imaging indicates that the FNPs can be used as fluorescent labels in bioanalysis.

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Rheological properties of wormlike micelles formed in the sodium oleate/trisodium phosphate aqueous solution

Yong Qiang Ji, Wei Shan Wang, Gan Zuo Li, Li Qiang Zheng

中国化学快报. 2008, 19(04): 483-487. https://doi.org/10.1016/j.cclet.2008.01.010

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Aqueous solution of anionic surfactant, sodium oleate (NaOA), was studied by means of steady-state shear rheology and dynamic oscillatory technique.The system of NaOA/Na₃PO₄ showed high viscosity, strong viscoelasticity and good ability of countering Ca²⁺, Mg²⁺.The Maxwell model and Cole-Cole plot were applied to study the dynamic viscoelasticity of wormlike micelles.The microstructures of the wormlike micelles were characterized by FF-TEM.

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New materials based on carbazole for optoelectronic device applications: Theoretical investigation

K. Hasnaoui, H. Zgou, M. Hamidi, M. Bouachrine

中国化学快报. 2008, 19(04): 488-492. https://doi.org/10.1016/j.cclet.2007.12.026

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A quantum-chemical investigation on the structural and optoelectronic properties of two materials based on carbazole is carried out.The purpose is to display the effect of grafting the fluorine atoms on their optoelectronic and pbysico-chemical properties.In addition to solubility in the polar solvents and the modification in geometric parameters, the substitution of fluorine destabilizes the HOMO and LUMO levels, decreases the band gap energy and raises conjugation length.These properties suggest the substituted fluorine compound as a good candidate for optoelectronic applications.

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Theoretical study on the synthesis reaction mechanism of trichlorogermyl crylic acid

Yu Zhen Fang, Chuan Lu, Jian Hua Zhou, Wan Yong Ma

中国化学快报. 2008, 19(04): 493-496. https://doi.org/10.1016/j.cclet.2008.01.036

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The synthesis reaction of trichlorogermyl crylic acid has been studied systematically by using quantum chemistry methods for the first time.Geometries of reactants, transition states, and products have been optimized, respectively at the B3LYP/6-311G (d, p) level.Vibrational frequencies, IR intensities and relative energies for various stationary points have been determined.The reaction pathways are identified by intrinsic reaction coordinate (IRC) calculations.Theoretical analysis provided conclusive evidence that the process is completed through five pathways of addition reaction of double bond, and the transition states are found to be fourmembered ring compounds.Solvent effects are taken into account with the PCM model at the same level.This preliminary study shows that the complex formation is favored by the use of polar solvent.

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A molecular dynamics simulation study of peptide deformylase from Leptospira interrogans complex: Exploring the closing mechanism of the substrate pocket

Qiang Wang, Jian Wu Wang, Zheng Ting Cai, Wei Ren Xu

中国化学快报. 2008, 19(04): 497-500. https://doi.org/10.1016/j.cclet.2008.01.027

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To explore the closing mechanism of the substrate pocket, we perform a 16, 000 ps molecular dynamics simulation separately on the ligand-free and actinonin-bound peptide deformylase from Leptospira interrogans. Our results show that the CD-loop, hydrophilic inhibitor and hydrophobic cluster are necessary for the formation of semi-open conformation, and Tyr71 plays an important role in mediating the movements of CD-loop. The average MD structure of the actinonin-bound LiPDF complex approaches to the crystal structure. These are consistent with experiment very well.

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Themoretical study on the potential energy surface and vibrational energy levels of HXeI

Zheng Guo Huang, En Cui Yang, Dai Qian Xie

中国化学快报. 2008, 19(04): 501-504. https://doi.org/10.1016/j.cclet.2008.01.041

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The potential energy surface for the electronic ground state of the HXeI molecule is constructed by using the internally contracted multi-reference configuration interaction with the Davidson correction (icMRCI+Q) method and large basis sets.The stabilities and dissociation barriers are identified from the potential energy surfaces.The three-body dissociation channel is found to be the dominate dissociation channel for HXeI.Based on the obtained potentials, vibrational energy levels of HXeI are calculated using the Lanczos algorithm.Our theoretical results are in excellent agreement with the available observed values.

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2008年, 第19卷, 第04期　刊出日期：2008-04-20

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2008年, 第19卷, 第04期 刊出日期：2008-04-20

2008年, 第19卷, 第04期　刊出日期：2008-04-20