Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation

Shiyang Sun, Ning Yang, Yaqiu Mao, Ting Wei, Pengli Wei, Tingting Yang, Yixin Zhang, Jian Yan, Changkai Jia, Yi Li, Xu Cai, Zhiyuan Zhao, Xuesong Feng, Xiaomei Zhuang, Wenpeng Zhang, Junhai Xiao, Pengyun Li, Zhibing Zheng, Song Li

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中国化学快报 ›› 2026, Vol. 37 ›› Issue (02) : 110992. DOI: 10.1016/j.cclet.2025.110992
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Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation

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Rational design of VHL-recruiting KRASG12C proteolysis-targeting chimeras based on molecular dynamics simulation

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{{article.zuoZheCn_L}}. {{article.title_cn}}. {{journal.qiKanMingCheng_CN}}. 2026, 37(02): 110992 https://doi.org/10.1016/j.cclet.2025.110992
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