A temperature-regulated bioorthogonal reaction to target lysine: Hemiacetal pharmacophore in genipin irreversibly binds with UCP2, inhibiting mitochondrial thermogenesis

Fukui Shen, Wen Yang, Kaixue Zhang, Yanting Jiao, Jing Cui, Yuanyuan Hou, Gang Bai

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中国化学快报 ›› 2023, Vol. 34 ›› Issue (10) : 108203. DOI: 10.1016/j.cclet.2023.108203
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A temperature-regulated bioorthogonal reaction to target lysine: Hemiacetal pharmacophore in genipin irreversibly binds with UCP2, inhibiting mitochondrial thermogenesis

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A temperature-regulated bioorthogonal reaction to target lysine: Hemiacetal pharmacophore in genipin irreversibly binds with UCP2, inhibiting mitochondrial thermogenesis

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{{article.zuoZheCn_L}}. {{article.title_cn}}. {{journal.qiKanMingCheng_CN}}. 2023, 34(10): 108203 https://doi.org/10.1016/j.cclet.2023.108203
{{article.zuoZheEn_L}}. {{article.title_en}}. {{journal.qiKanMingCheng_EN}}. 2023, 34(10): 108203 https://doi.org/10.1016/j.cclet.2023.108203

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