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CCL   2017 28( 09)  Published: 22 September 2017
 
Highlight
Cell-surface cascaded landing location for nanotheranostics
En Ren, Junqing Wang, Gang Liu
CCL 2017 Vol. 28 (09): 1799-1800   DOI:10.1016/j.cclet.2017.07.015
Abstract |  PDF (162 KB)  ( 243 ) | HTML ( )
Cell-surface cascaded landing location is an effective strategy to develop functional drug-loading platforms to explore basic physiological processes at the cellular level and to facilitate the development of nanotheranostics for disease treatment.
Reviews
Artificial periosteum in bone defect repair-A review
Quan Wang, Jianxiang Xu, Haiming Jin, Wenhao Zheng, Xiaolei Zhang, Yixing Huang, Zhiyong Qian
CCL 2017 Vol. 28 (09): 1801-1807   DOI:10.1016/j.cclet.2017.07.011
Abstract |  PDF (435 KB)  ( 95 ) | HTML ( )
We review the development of artifi cial periosteum and classify it into three approaches based on the material source, that is, native tissues, scaffoldfree cell sheets and scaffold-cell composites. Mechanisms, methods and effi cacy of each approach are provided. Existing obstacles and enabling technologies for future directions are also discussed.
Recent advances of transformable nanoparticles for theranostics
Kuo Zhang, Pei-Pei Yang, Jing-Ping Zhang, Lei Wang, Hao Wang
CCL 2017 Vol. 28 (09): 1808-1816   DOI:10.1016/j.cclet.2017.07.001
Abstract |  PDF (986 KB)  ( 93 ) | HTML ( )
We summary recent advances of transformable NPs for nanomedicine. In this review, the transformation of NPs is divided into three groups including changes in size, surface charge and morphology, which is induced by internal stimuli, such as pH, enzyme, receptor or external stimuli, such as light, temperature.
Pediatric ocular nanomedicines:Challenges and opportunities
Natasha D. Sheybani, Hu Yang
CCL 2017 Vol. 28 (09): 1817-1821   DOI:10.1016/j.cclet.2017.07.022
Abstract |  PDF (339 KB)  ( 61 ) | HTML ( )
Challenges and opportunities to development of ocular drug delivery systems and nanomedicines for pediatric patients are reviewed.
Recent progress on DNA block copolymer
Gaifang Pan, Xin Jin, Quanbing Mou, Chuan Zhang
CCL 2017 Vol. 28 (09): 1822-1828   DOI:10.1016/j.cclet.2017.08.022
Abstract |  PDF (627 KB)  ( 79 ) | HTML ( )
Organic polymers are combined with DNA resulting DNA block copolymers (DBCs) that can simultaneously show the properties of the polymer and DNA. We will discuss some examples of recent developments in the syntheses, structure manipulations, and applications of DBCs.
Development and application of nano-flavor-drug carriers in neurodegenerative diseases
Wei-Hong Ji, Zuo-Bing Xiao, Gui-Ying Liu, Xin Zhang
CCL 2017 Vol. 28 (09): 1829-1834   DOI:10.1016/j.cclet.2017.06.024
Abstract |  PDF (183 KB)  ( 70 ) | HTML ( )
Nano-drug carriers such as liposomes, polymer micelles, and polymer nanoparticles are used for neurodegenerative diseases, which can help drug pass the blood-brain barrier easily, and improve the therapeutic effect.
Self-assembled small molecular weight hydrogels of prodrugs
Yanfang Zhou, Xingyi Li
CCL 2017 Vol. 28 (09): 1835-1840   DOI:10.1016/j.cclet.2017.04.033
Abstract |  PDF (381 KB)  ( 69 ) | HTML ( )
Prodrugs as building unit for construction of various hydrogelator in response to different stimulus (e.g., temperature, enzyme, pH value, ion).
H2O2-responsive theranostic nanomedicine
Luodan Yu, Yu Chen, Hangrong Chen
CCL 2017 Vol. 28 (09): 1841-1850   DOI:10.1016/j.cclet.2017.05.023
Abstract |  PDF (1313 KB)  ( 65 ) | HTML ( )
This review summarizes and discusses the very-recent developments of H2O2-responsive theranostic nanoplatforms for versatile biomedical applications, including diagnostic imaging, attenuating tumor hypoxia, enhancing the therapeutic effi ciency of photodynamic therapy/radiation therapy/chemotherapy and theranostic of inflammation/diabetic. It is highly believed that H2O2-responsive theranostic nanomedicine will be extensively developed a new specifi c and effi cient theranostic modality to benefi t the personalized biomedicine in the near future.
Advances in quantum dot-mediated siRNA delivery
Zhi-Yao He, Zhao-Hui Jin, Mei Zhan, Zhou Qin, Zhi Li, Ting Xu
CCL 2017 Vol. 28 (09): 1851-1856   DOI:10.1016/j.cclet.2017.07.012
Abstract |  PDF (329 KB)  ( 43 ) | HTML ( )
Quantum dot-mediated siRNA theranostic systems enhance the siRNA delivery, and track the uptake and distribution of siRNA.
The design, mechanism and biomedical application of self-healing hydrogels
Qiwen Li, Chenlu Liu, Junru Wen, Yongzhi Wu, Yue Shan, Jinfeng Liao
CCL 2017 Vol. 28 (09): 1857-1874   DOI:10.1016/j.cclet.2017.05.007
Abstract |  PDF (1275 KB)  ( 90 ) | HTML ( )
Current advances made in self-healing hydrogels relating to the design strategies, self-healing mechanism, testing methods and biomedical application in vivo were extensively reviewed in this article.
Communications
PEGylated BODIPY assembling fluorescent nanoparticles for photodynamic therapy
Yu Zhu, Wenhai Lin, Wei Zhang, Yuqin Feng, Zhineng Wu, Li Chen, Zhigang Xie
CCL 2017 Vol. 28 (09): 1875-1877   DOI:10.1016/j.cclet.2017.06.017
Abstract |  PDF (311 KB)  ( 119 ) | HTML ( )
Two PEGylated BODIPY which could self-assemble into nanoparticles were synthesized via multicomponent Passerini reaction for cellular imaging and photodynamic therapy.
pH Readout enhanced ELISA for point-of-care testing of cardiac troponin I
Luyang Miao, Lianhua Zhang, Lei Jiao, Xiaofeng Tan, Qin Wei, He Li
CCL 2017 Vol. 28 (09): 1878-1880   DOI:10.1016/j.cclet.2017.04.018
Abstract |  PDF (242 KB)  ( 66 ) | HTML ( )
In this study, we described a pH ELISA using synthetic melanin nanoparticles (SMNPs) for the co-immobilization of glucose oxidase and second antibody as signal labels, portable pH meter as signal readout device for detecting biomarker of myocardial injury. This assay is easy-to-use, portable, sensitive and able to realize point-of-care testing (POCT), which was demonstrated the signifi cant promising in the early diagnosis and screening of acute myocardial infarction.
Immune fluorescence test strips based on quantum dots for rapid and quantitative detection of carcino-embryonic antigen
Yudong Wu, Weipan Peng, Qian Zhao, Jiafang Piao, Bo Zhang, Xiaoli Wu, Hanjie Wang, Zhihong Shi, Xiaoqun Gong, Jin Chang
CCL 2017 Vol. 28 (09): 1881-1884   DOI:10.1016/j.cclet.2017.07.026
Abstract |  PDF (325 KB)  ( 42 ) | HTML ( )
A QDs-based immune fl uorescence test strips was built up for carcino-embryonic antigen detection to realize cancers POCT diagnostic, with a sensitivity of 0.72 ng/mL in 25 min.
Fabrication of a polypseudorotaxane nanoparticle with synergistic photodynamic and chemotherapy
Tao-Tao Xu, Jun-Hua Li, Fu-Rong Cheng, Yi-Xin Zhang, Jun Cao, Wen-Xia Gao, Bin He
CCL 2017 Vol. 28 (09): 1885-1888   DOI:10.1016/j.cclet.2017.07.029
Abstract |  PDF (424 KB)  ( 109 ) | HTML ( )
Polypseudorotaxane (PPR) nanoparticles were fabricated by the self-assembly of mPEG-protoporphyrin IX (PpIX) conjugate and a-CDs via the hostguest interaction for achieving synergistic photodynamic and chemotherapy.
C60(OH)n-loaded nanofibrous membranes protect HaCaT cells from ROS-associated damage
Mengyu Guo, Shuying Bi, Jing Liu, Wenshi Xu, Guoqiang Zhou, Ying Liu, Chunying Chen
CCL 2017 Vol. 28 (09): 1889-1892   DOI:10.1016/j.cclet.2017.07.021
Abstract |  PDF (387 KB)  ( 38 ) | HTML ( )
C60(OH)n-loaded nanofi brous membranes were prepared by electrospinning to suppress the elevation of intracellular ROS and Ca2+, and to protect human keratinocyte cells from ROS-associated damage and apoptosis.
A potential flower-like coating consisting of calcium-phosphate nanosheets on titanium surface
Quanquan Ma, Jinfeng Liao, Taoran Tian, Qi Zhang, Xiaoxiao Cai
CCL 2017 Vol. 28 (09): 1893-1896   DOI:10.1016/j.cclet.2017.07.028
Abstract |  PDF (296 KB)  ( 64 ) | HTML ( )
A potential calcium-phosphate fl ower-like nanocoating were coated onto the titanium surface in an easy approach. It has high surface area, low cytotoxicity as well as promising cell affi nity, which makes it a potential alternative modifi cation method for titanium surface.
Biocompatible microcapsules with a water core templated from single emulsions
Linlin Kong, Esther Amstad, Mingtan Hai, Xinyou Ke, Dong Chen, Chun-Xia Zhao, David A. Weitz
CCL 2017 Vol. 28 (09): 1897-1900   DOI:10.1016/j.cclet.2017.07.017
Abstract |  PDF (330 KB)  ( 53 ) | HTML ( )
We use single emulsions as templates to fabricate monodisperse biocompatible microcapsules with a water core. These microcapsules are fabricated using FDA-approved polymer and non-toxic solvents and are of great use in drugs, cosmetics and foods.
11-Mercaptoundecanoic acid functionalized gold nanoclusters as fluorescent probes for the sensitive detection of Cu2+ and Fe3+ ions
Zhiqun Bai, Xiangling Ren, Zhen Gong, Chenxi Hao, Yongmei Chen, Pingyu Wan, Xianwei Meng
CCL 2017 Vol. 28 (09): 1901-1904   DOI:10.1016/j.cclet.2017.05.005
Abstract |  PDF (302 KB)  ( 87 ) | HTML ( )
A facile synthetic fl uorescent 11-MUA-Au NCs was applied to rapid and quantitative detection of Cu2+ and Fe3+ ions.
Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems
Chunyan Hu, Zhuo Chen, Shengjie Wu, Yanfeng Han, Hai Wang, Hongfan Sun, Deling Kong, Xigang Leng, Chun Wang, Linhua Zhang, Dunwan Zhu
CCL 2017 Vol. 28 (09): 1905-1909   DOI:10.1016/j.cclet.2017.07.020
Abstract |  PDF (281 KB)  ( 70 ) | HTML ( )
Polymeric micelles and polymersomes may have great potential as the drug delivery vehicles for solubilization of hydrophobic drugs.
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