Bioactive compounds from <em>Selaginella involven</em> Spring that protect PC-12 cells

doi:10.1016/j.cclet.2014.03.024

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Abstract

Two new compounds named as 3β,12,16-trihydroxy-6,8,11,13-abietatrien (1), (8R,8'S)-4,4',8-trihy-droxyl- 3,3'-dimethoxyl-9'-lignanolide (2) and a new natural product 4,4'-dihydroxyl-3,3',5,5'- dimethoxyldiphenyl diketone (3) were isolated from the whole herbs of Selaginella involven Spring. The structures were elucidated by spectroscopic analyses including UV, IR, 1D, 2DNMR and MS methods. Additionally, these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.

Key words： Selaginella Selaginella involven Spring Abietane diterpenoid Lignans PC-12 cell

Received: 13 January 2014 Published: 15 March 2014

Fund:

This research was supported by National Natural Science Foundation (No. 31370370), the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057), Chinese Medicine Research Program of Hunan Province (Nos. 2009059 and 2010004).

Corresponding Authors: Gui-Shan Tan E-mail: tgs395@aliyun.com

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http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2014.03.024 OR http://www.chinchemlett.com.cn/EN/Y2014/V25/I05/805

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