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Bioactive compounds from Selaginella involven Spring that protect PC-12 cells |
Hong-Ping Longa, Fu-Shuang Lia, Kang-Ping Xua, Zhong-Bao Yanga, Jing Lia, Jun Penga, Gui-Shan Tana,b |
a School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;
b Xiangya Hospital of Central South University, Changsha 410008, China |
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Abstract Two new compounds named as 3β,12,16-trihydroxy-6,8,11,13-abietatrien (1), (8R,8'S)-4,4',8-trihy-droxyl- 3,3'-dimethoxyl-9'-lignanolide (2) and a new natural product 4,4'-dihydroxyl-3,3',5,5'- dimethoxyldiphenyl diketone (3) were isolated from the whole herbs of Selaginella involven Spring. The structures were elucidated by spectroscopic analyses including UV, IR, 1D, 2DNMR and MS methods. Additionally, these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.
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Received: 13 January 2014
Published: 15 March 2014
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Fund: This research was supported by National Natural Science Foundation (No. 31370370), the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057), Chinese Medicine Research Program of Hunan Province (Nos. 2009059 and 2010004). |
Corresponding Authors:
Gui-Shan Tan
E-mail: tgs395@aliyun.com
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