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| Lipase-catalyzed Knoevenagel condensation between α, β-unsaturated aldehydes and active methylene compounds |
| Zhi Wanga, Chun-Yu Wangc, Hao-Ran Wanga, Hong Zhanga, Ya-Lun Sub, Teng-Fei Jib, Lei Wanga |
a Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, College of Life Science, Jilin University, Changchun 130023, China;
b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
c State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130023, China |
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Abstract A simple and efficient Knoevenagel condensation between α,β-unsaturated aldehydes and active methylene compounds is reported. Notably, this condensation can be catalyzed by PPL (lipase from porcine pancreas) with satisfied yields (49%-92%). Moreover, PPL induces moderate Z/E selectivity in the Knoevenagel condensation.
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Received: 15 January 2014
Published: 05 April 2014
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| Fund: The authors are grateful for the financial support from the National Natural Science Foundation of China (Nos. 21172093, 31070708, and 21072075), the Natural Science Foundation of Jilin Province of China (Nos. 201115039 and 20140101141JC) and the Scientific Research Fund of Jilin University (No. 450060326007). |
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Corresponding Authors:
Teng-Fei Ji, Lei Wang
E-mail: jitf@imm.ac.cn;w_lei@jlu.edu.cn
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