Abstract A facile approach for the first total synthesis of naturally occurring geranylated flavanoids sepicanin A has been obtained with total yield 16% starting from 2, 4, 6-trihydroxyacetophenone after four steps. The key step was the protic acids (HCl or p-TsOH)-catalyzed benzopyrone formation in a protic polar solvent by deprotection and cyclization of chalcone in one step.
Received: 06 September 2011
Fund:This work was financially supported by the National Natural Science Foundation (No. 20962016) and Ningxia Natural Science Foundation (No. NZ1006) and Program for New Century Excellent Talents in University (No. NCET-09-0860).
Jin Hui Yang,E-mail address:firstname.lastname@example.org