Recent advances on iron-catalyzed coupling reactions involving organolithium reagents

doi:10.1016/j.cclet.2019.05.026

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Guide Several iron-catalyzed cross- and homo-coupling reactions involving organolithiums were developed to form diverse carbon-carbon bonds. The usefulness of this protocol was demonstrated by producing gram-scale products in good yields.

Abstract Owing to their inexpensive and environmentally friendly properties, iron-based catalysts have been actively investigated for new organic reactions. In this account, we summarized our recent results on iron-catalyzed cross-coupling reactions and homo-coupling reactions. With iron-based catalysts, we constructed diverse carbon-carbon bonds, i.e., C(sp²)-C(sp³), C(sp³)-C(sp³), C(sp³)-C(sp²) and C(sp²)-C(sp²) bonds. In order to demonstrate the usefulness of our iron protocol, we also carried out these reactions on gram-scale reactions, leading to good yields

Key words： Iron-catalyzed Cross-coupling Homo-coupling Organolithium Gram-scale

Received: 03 April 2019

Fund:This work was financed by National Natural Science Foundation of China (Nos. 21672181, 21272199), GRF/RGC (Nos. 403012, CUHK14309216, CUHK14303815), grant to the State Key Laboratory of Synthetic Chemistry from the Innovation and Technology Commission, The Chinese Academy of Sciences-Croucher Foundation Funding Scheme for Joint Laboratories, and Direct Grant (No. 4053325) from The Chinese University of Hong Kong.

Corresponding Authors: Henry N. C. Wong E-mail: hncwong@cuhk.edu.hk

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	Zhuliang Zhong
	Xiao-Shui Peng
	Henry N. C. Wong

Cite this article:

Zhuliang Zhong,Xiao-Shui Peng,Henry N. C. Wong. Recent advances on iron-catalyzed coupling reactions involving organolithium reagents[J]. Chinese Chemical Letters, 2019, 30(08): 1463-1467.

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http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2019.05.026 OR http://www.chinchemlett.com.cn/EN/Y2019/V30/I08/1463

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