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| Hyperbranched polylysine: Synthesis, mechanism and preparation for NIR-absorbing gold nanoparticles |
| Yiying Ge, Pan Li, Yanfei Guan, Chang-Ming Dong |
| School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China |
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| Guide The hyperbranched polylysine fluoroborate was synthesized by NH3BF4-Lys NCA ROP in triethylamine at 15℃, during which the cyclic dimer mainly initiated ROP as the secondary initiating species. The hyperbranched polylysine can be used as a stabilizer to prepare the NIR-absorbing HPlys@Au NPs. |
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Abstract The ring-opening polymerization (ROP) of N-(tetrafluoroboran ammonium)-L-lysine-N-carboxyanhydride (NH3BF4-Lys NCA) was initiated by triethylamine to prepare hyperbranched polylysine (HPlys) fluoroborate with narrow polydispersity at a low temperature. Both mass spectroscopy analysis and DFT computation evidenced that the resultant cyclic dimer mainly initiated ROP as a secondary species according to normal amine mechanism. The hyperbranched polylysine in aqueous solution existed in a unimolecular state at low concentrations, but transformed into spherical micellar aggregates at a high concentration of 5 mg/mL, as characterized by dynamic laser scattering and transmission electron microscopy. By utilizing multivalent coordination interactions between hyperbranched polylysine and gold, the plasmonic gold nanoparticles (HPlys@Au NPs) were successfully prepared in aqueous solution, which elevated the solution by 23.1℃ upon 5 min of NIR laser irradiation (808 nm, 2 W/cm2).
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Received: 07 January 2019
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| Fund:This work was supported by the National Natural Science Foundation of China (No. 21474061), the Innovation Program of Shanghai Municipal Education Commission (No. 201701070002E0061), and the Innovation Fund (No. IFPM2016B004) of Shanghai Jiao Tong University & Affiliated Sixth People's Hospital South Campus are appreciated. |
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Corresponding Authors:
Chang-Ming Dong
E-mail: cmdong@sjtu.edu.cn
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