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| Synthesis of cyclic peptide reniochalistatin E and conformational isomers |
| Huiyun Luoa, Hongli Yinb, Chaojun Tangc, Ping Wangb, Feng Lianga |
a The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, China;
b Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;
c Chonqqing Huapont Pharm. Co., Ltd., Chongqing 401121, China |
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| Guide Here we describe a convergent synthesis of reniochalistatin E that utilized solid-phase peptide synthesis. For macrolactamization of the linear peptides without the side chain protecting group, we obtained reniochalistatin E and its conformational isomers with 32% isolation yield. |
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Abstract Here, we report a convenient and efficient synthesis strategy for the total synthesis of cyclic peptide reniochalistatin E and its conformational isomers with 32% overall yield. We found the linear peptide precursor without side chain gave better cyclization yield.
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Received: 15 March 2018
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| Fund:This work is supported by the National Natural Science Foundation of China (No. 21372183), and Program for Innovative Teams of Outstanding Young and Middle-aged Researchers in the Higher Education Institutions of Hubei Province (No. T201702). |
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Corresponding Authors:
Ping Wang, wangp1@sjtu.edu.cn;Feng Liang, feng_liang@wust.edu.cn
E-mail: wangp1@sjtu.edu.cn;feng_liang@wust.edu.cn
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