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| Programmable pyrrole-imidazole polyamides: A potent tool for DNA targeting |
| Chunlei Wu, Wei Wang, Lijing Fang, Wu Su |
| Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China |
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| Guide Pyrrole-imidazole (Py-Im) polyamides are a class of programmable minor-groove binders that recognize pre-determined DNA double helixes with high affinity and specificity. This review summarized the recent advances of Py-Im polyamides from their synthesis to applications via various modifications at the molecular level. |
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Abstract Hairpin pyrrole-imidazole (Py-Im) polyamides are a class of programmable minor-groove binders that recognize pre-determined DNA double helixes with high affinity and specificity. They are capable of regulating gene expression by modulating the activity of transcription factors. To date, Py-Im polyamides have been successfully applied as a potent tool to disturb DNA functions and considered as a group of promising candidates for the clinical applications. Herein, this review will focus on summarizing the recent advances of Py-Im polyamides from their synthesis to applications via various modifications at the molecular level.
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Received: 09 April 2018
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| Fund:This work was supported by the Shenzhen Sciences & Technology Innovation Council (Nos. GJHS20170314154409805, GJHS20160331195142827, GJHS20150417103343317, JCYJ201708 1815358196, JCYJ20150401150223649 and JCYJ20170413165 916608) and the National Natural Science Foundation of China (Nos. 21672254, 21778068, 21502219 and 21432003). |
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Corresponding Authors:
Lijing Fang, lj.fang@siat.ac.cn;Wu Su, wu.su@siat.ac.cn
E-mail: lj.fang@siat.ac.cn;wu.su@siat.ac.cn
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