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| Different stapling-based peptide drug design: Mimicking α-helix as inhibitors of protein-protein interaction |
| Xiang Li, Yan Zou, Hong-Gang Hu |
| School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Guide We category and analyze key examples of various peptide stapling strategies based on different cross-links aligned on the side chain of peptides mainly in the last three years. |
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Abstract Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptides feature a covalent cross-link of side chains, thus effectively mimicking α-helix as inhibitors of protein-protein interactions. In this review, we category and analyze key examples of various peptide stapling strategies based on different cross-links aligned on the side chain of peptides mainly in the last three years.
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Received: 07 December 2017
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Corresponding Authors:
Hong-Gang Hu, hhu66@smmu.edu.cn
E-mail: hhu66@smmu.edu.cn
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