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| Methods for engineering therapeutic peptides |
| Yaohao Li, Kimberly A. Clark, Zhongping Tan |
| Department of Chemistry and Biochemistry and BioFrontiers Institute, University of Colorado, Boulder CO 80303, United States |
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| Guide This review discussed recent advancements related to therapeutic peptide engineering. |
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Abstract Peptides are a class of drugs that have become increasingly important and influential for the treatment of many human diseases. Compared to traditional small molecule drugs, peptides have the potential for higher target specificity and potency, along with better safety profiles. On the other hand, the complex and fragile nature of peptides poses significant challenges for their administration. Of particular concern is that they are often unstable and can be rapidly degraded by various proteases after dosing. To address these inherent problems of peptides, many different methods have been attempted. Here, we briefly review these methods, with an emphasis on the effect of each method.
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Received: 23 April 2018
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| Fund:We are thankful for the support from the University of Colorado Boulder (Start-up Fund) and the National Science Foundation CAREER Award (No. CHE-1454925) during the course of this study. |
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Corresponding Authors:
Zhongping Tan, zhongping.tan@colorado.edu
E-mail: zhongping.tan@colorado.edu
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