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| Discovery, structure, and chemical synthesis of disulfide-rich peptide toxins and their analogs |
| Ge-Min Fanga, Xiao-Xu Chena, Qian-Qian Yangb, Liang-Jing Zhub, Ning-Ning Lib, Hai-Zhu Yub, Xiang-Ming Mengb |
a Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, China;
b Department of Chemistry, Anhui University, Hefei 230601, China |
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| Guide Disulfide bond-rich peptide toxins are promising scaffolds for the development of medicinal peptides because they possess a rigid 3D structure formed by multiple disulfide bonds. In this review, we discussed recent advances in the discovery, structural elucidation and chemical synthesis of disulfide-rich peptide toxins and their analogs. |
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Abstract Recently, medicinal peptide molecules are of great interest to many international pharmaceutical companies, mainly because of their relatively lower research costs, shorter research cycles, and the greater likelihood of being drugs, when compared with traditional small molecules. Due to the great variety in molecule structures and the diverse biological functions, disulfide-rich peptide toxins have become a shining molecular library for the development of polypeptide drugs. In view of the increasing amount of related publications, here we summarize the discovery, structural elucidation and chemical synthesis of disulfide-rich peptide toxins and their analogs.
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Received: 28 November 2017
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| Fund:This work was supported by National Natural Science Foundation of China (No. 21778001). |
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Corresponding Authors:
Ge-Min Fang, fgmsxy@gmail.com;Xiang-Ming Meng, mengxm@ahu.edu.cn
E-mail: fgmsxy@gmail.com;mengxm@ahu.edu.cn
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