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| Discovery and biosynthesis of thioviridamide-like compounds |
| Jian Tang, Jingxia Lu, Qunfeng Luo, Huan Wang |
| State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China |
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| Guide Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptide and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyl]-D-cysteine (AviCys). Members of this family are active against a number of cancer cell lines. As a unique subgroup of RiPPs, the distribution, biosynthetic machinery and the mode of action of thioviridamide and related compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin. |
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Abstract Thioviridamide-like compounds are a unique subfamily of ribosomally synthesized and post-translationally modified peptides and contain characteristic thioamide bonds and S-[(Z)-2-aminovinyl]-Dcysteine (AviCys). Members of this family are active against a number of cancer cell lines. The distribution, biosynthetic machinery and the mode of action of thioviridamide-like compounds remain largely unknown. In this review, we outlined recent advances in the discovery of thioviridamide-like peptide natural products and the effort in the elucidation of their biosynthetic origin.
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Received: 15 March 2018
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| Fund:This work is supported by the 1000-Youth Talents Plan, NSF of China (No. 21778030), Natural Science Foundation of Jiangsu Province (No. BK20160640) and the Fundamental Research Funds for the Central Universities. |
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Corresponding Authors:
Huan Wang, wanghuan@nju.edu.cn
E-mail: wanghuan@nju.edu.cn
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