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| A mini-review on the enzyme-mediated manipulation of proteins/peptides |
| Shaomin Lin, Chunmao He |
| School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China |
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| Guide A number of enzymes are available in the toolbox facilitating the site-selective labeling, ligation, cyclization of proteins or peptides. In this review, some of the most important enzymes were discussed. |
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Abstract Recent years have seen an ever increasing number of enzyme mediated protein/peptide modification reactions, which contribute significantly to the elucidation of related biological functions. The many available enzymes have, however, caused difficulties for practitioners in choosing the most appropriate enzyme for a certain purpose. This review surveyed the widely used enzymes (i.e., sortases, butelase 1, subtiligase, formylglycine generating enzyme and farnesyltransferase) in the manipulation of proteins/peptides, and the application fields of these enzymes as well as the advantages and limitations of each enzyme are summarized.
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Received: 14 April 2018
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| Fund:The financial support from the National Recruitment Program of Global Youth Experts (1000 Talents Plan) and the National Natural Science Foundation of China (No. 81703406) are greatly acknowledged. |
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Corresponding Authors:
Chunmao He, hecm@scut.edu.cn
E-mail: hecm@scut.edu.cn
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