Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery

doi:10.1016/j.cclet.2017.09.048

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Guide The redox-responsive hybrid nanoparticles of P(MACPTS-co-MAGP)@AgNPs is developed for drug delivery and fluorescence monitoring of the drug release by applying the NSET-based strategy.

Abstract A drug carrier system of the hybrid nanoparticles based on the redox-responsive P[(2-((2-((camptothecin)-oxy)ethyl)disulfanyl)ethylmethacrylate)-co-(2-(D-galactose)methylmethacryl-ate)] (P (MACPTS-co-MAGP)) and AgNPs is developed to deliver the anti-cancer drug camptothecin (CPT) and monitor the drug release by the recovery of the fluorescence of CPT. CPT is linked to the polymer sidechains via a redox-responsive disulfide bond, attaching on the surface of AgNPs and leading to the quenching of CPT fluorescence ("off" state) due to the nanoparticle surface energy transfer (NSET) effect. Upon the exposure to glutathione (GSH), the disulfide bond is cleaved to release CPT, resulting in the recovery of the fluorescence of CPT ("on" state). The system offers a platform to track the CPT delivery and releasing in real time

Key words： Redox-responsive Drug delivery system Hybrid nanoparticles NSET effect

Received: 20 June 2017

Fund:This work was supported by the National Natural Science Foundation of China (No. 21574037), the "100 Talents" Program of Hebei Province, China (No. E2014100004), the Natural Science Foundation of Hebei Province (Nos. B2015202330, B2017202051), the Program for Top 100 Innovative Talents in Colleges and Universities of Hebei Province (No. SLRC2017028) and the Tianjin Natural Science Foundation (No. 15JCYBJC17500).

Corresponding Authors: Chengfen Xing E-mail: xingc@hebut.edu.cn

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http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2017.09.048 OR http://www.chinchemlett.com.cn/EN/Y2018/V29/I02/301

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