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| Fimbrialtols K-M, highly functionalized ent-kaurane diterpenoids from traditional Chinese plant Flickingeria fimbriata (B1.) Hawkes |
| Gang Dinga, Jing Wanga,b, Jiao-Dong Feia,b, Rong-Tao Lic, Hong-Mei Jiaa, Tao Zhanga, Chang-Yuan Yub, Zhong-Mei Zoua |
a Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China;
b Beijing University of Chemical Technology, Beijing 100029, China;
c Hainan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China |
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Abstract Three new ent-kaurane diterpenoids fimbrialtols K-M (3-5) with highly substituted functionalities were isolated from the extract of Flickingeria fimbriata (B1.) Hawkes. The structures of these new compounds were determined by NMR and HR-ESIMS. The relative configurations of these compounds were determined by analysis of NOESY correlations. The absolute configurations of these new compounds were established by CD methods together with considering the biosynthetic pathway. Compounds 3 and 4 contain a cinnamic carboxyl group, whereas compound 5 possesses a benzoic carboxyl group representing the first report in more than known 600 ent-kaurane diterpenoids.
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Received: 17 August 2016
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| Fund:This work was financially supported by the Chinese National S&T Special Project on Major New Drug Innovation (No. 2013ZX09508104),the Fundamental Research Funds for the Central Scientific Research Institutes for Public Welfare, CAMS Innovation Fund for Medical Sciences (CIFMS, No.2016-I2M-3-015). |
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Corresponding Authors:
Chang-Yuan Yu, Zhong-Mei Zou
E-mail: yucy@mail.buct.edu.cn;zmzou@implad.ac.cn
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