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| Convenient synthesis of chiral H4-BINOL via direct hydrogenation of BINOL |
| Qian Chang Ding, Yun Feng Du, Xin Sheng Li, Dong Cheng Xu |
| Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, 321004, China |
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Abstract A simple, highly effective hydrogenation of chiral BINOL to provide H4-BINOL in multigram scale with good yield (up to 78% yield) was developed. A series of heterogeneous catalysts was tested in the hydrogenation; the best result was obtained with 5% Pd/C in EtOH under the H2 pressure of 50 bar for 2 h. This method is a more useful method for practical synthesis of optically pure H4-BINOL than other available methods.
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Received: 19 January 2010
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| Fund:The project was supported by the Science and Technology Department of Zhejiang Province (no.2008C21041) and was partially supported by the NSFC (no.20572101). |
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Corresponding Authors:
Xin Sheng Li,E-mail address:sky33@zjnu.cn
E-mail: sky33@zjnu.cn
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| About author:: 10.1016/j.cclet.2010.07.013 |
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