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| Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatin Ⅵ |
| Jun Chao Shao, Zhi Hua Ye, Hai Xia Lin, Dian Long Wang, Na Han |
| Department of Chemistry, Shanghai University, Shanghai 200444, China |
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Abstract New D-seco-taxoids were synthesized from 1-deoxybaccatin Ⅵ and their structures were confirmed by 1H NMR, 13C NMR, ESIMS and X-ray crystallography. The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance (MDR) reversal agents and new synthetic precursors of paclitaxel analogues.
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Received: 15 January 2010
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| Fund:The authors are grateful to the National Natural Science Foundation of China (No.30672506) and Leading Academic Discipline Project of Shanghai Municipal Education Commission (No.J50102). |
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Corresponding Authors:
Hai Xia Lin,E-mail address:haixialin@staff.shu.edu.cn
E-mail: haixialin@staff.shu.edu.cn
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| About author:: 10.1016/j.cclet.2010.07.001 |
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