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| An efficient and green preparation of 5-aminophosphonate substituted pyrimidine nucleosides under solvent-free conditions |
| Xin Ying Zhang, Ying Ying Qu, Xue Sen Fan |
| School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang 453007, China |
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Abstract An environmentally benign and highly efficient one-pot preparation of α-aminophosphonates under solvent-free conditions was developed. By employing this method, 5-aminophosphonate substituted pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2'-deoxyuridine, aniline and dimethylphosphite.
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Received: 25 February 2010
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| Fund:We are grateful to the National Natural Science Foundation of China (Nos.20772025 and 20972042),the Program for Science&Technology Innovation Talents in Universities of Henan Province (No.2008HASTIT006),Innovation Scientists and Technicians Troop Construction Projects of Henan Province (No.104100510019) and the Natural Science Foundation of Henan Province (Nos.092300410192 and 094300510054). |
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Corresponding Authors:
Xue Sen Fan,E-mail address:xuesen.fan@yahoo.com
E-mail: xuesen.fan@yahoo.com
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| About author:: 10.1016/j.cclet.2010.04.037 |
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