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| A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis |
| Ming Ming Yana, Ting You Lib, Da Qing Zhaoa, Shuai Shaoa, Sheng Nan Bia |
a Changchun University of Chinese Medicine, Changchun 130117, China;
b School of Pharmacy, Nanjing Medical University, Nanjing 210029, China |
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Abstract A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-(hydroxyacetyl)-23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC50 value of 7.77±0.47 μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-dipbenyltetrazolium bromide(MTT)method.
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Received: 12 November 2009
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Corresponding Authors:
Ming Ming Yan,E-mail address:yanmm595@yahoo.com.cn
E-mail: yanmm595@yahoo.com.cn
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