Abstract Reactions of the 6-hydroxy-thiopyrano [3,4-c]pyridine-5-carbonitrile derivative 1 with α-halo-carbonyl compounds gave the ortho-substituted intermediates 2a-c which were converted into furo [2,3-b]thiopyrano [4,3-d]pyridines 3a-c by fusion of a furan moiety under basic conditions. Further cyclization of 3a-c led to a fusion of a pyrimidine ring, yielding the tetracyclic products 6,7 and 8. In addition, condensation of 6 with various aromatic aldehydes afforded the corresponding imines 9a,b. Mannich reaction of 7 gave products 10a,b.
Received: 23 September 2009
Mohamed A. Ameen,E-mail address:email@example.com