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| A new sesquiterpene from hairy root culture of Artemisia annua |
| Dan Dan Zhaia, Hui Zi Jinb, Jian Jiang Zhonga,c |
a State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China;
b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;
c Key Laboratory of Microbial Metabolism, Ministry of Education, School of Life Sciences & Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China |
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Abstract A new sesquiterpene (Z)-7-acetoxy-methyl-11-methyl-3-methylenedodeca-1,6,10-triene (AMDT) was isolated and identified from the methanol extract of the hairy root culture of Artemisia annua. The structure of AMDT was determined based on the analysis of spectroscopic data, notably of the 2D NMR spectra. This new compound showed cytotoxicity against human tumor cell lines 95-D and HeLa with IC50 values of 27.08 and 20.12 μmol/L, respectively.
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Received: 25 August 2009
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| Fund:Financial support from the Shanghai Leading Academic Discipline Project (No. B203 and B505) is gratefully acknowledged. Dr. Kanyaratt Supaibulwatana of Department of Biotechnology, Mahidol University, Thailand, kindly provided us with the hairy root culture. We also thank Prof. Weimin Zhao in the Shanghai Institute of Materia Medica for his help with the structure analysis. |
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Corresponding Authors:
Jian Jiang Zhong,E-mail address:jjzhong@sjtu.edu.cn
E-mail: jjzhong@sjtu.edu.cn
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| [1] |
Qin-Peng Shen, Xing-Meng Xu, Lan Li, Wei Zhao, Neng-Jun Xiang, Guang-Yu Yang, Yong-Kuan Chen, Ming-Ming Miao, Chun-Bo Liu, Zhi-Hua Liu. Sesquiterpenes from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activity[J]. CCL, 2016, 27(05): 753-756. |
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