Abstract Four novel 5-substituted pyridine-2(1H)-one derivatives were designed and synthesized by using addition-elimination reactions. The structures of these novelly synthesized compounds were verified by 1H NMR, ESI-MS and single crystal X-ray diffraction. Furthermore, all four compounds (most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG22.2.15 cell, making them promising drug candidates for potential bioactive molecule against hepatitis B.
Received: 06 July 2009
Ke Li,E-mail address:firstname.lastname@example.org