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| Oxa-Pictet-Spengler reaction in water. Synthesis of some (±) 1-aryl-6,7-dimethoxyisochromans |
| Aamer Saeed |
| Department of Chemistry, Quaid-I-Azam University, 45320 Islamabad, Pakistan |
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Abstract An acid catalyzed oxa-Pictet-Spengler reaction ‘on water’ leading to the synthesis of a variety of 1-aryl-6,7-dimethoxyisochro-mans is described. The aqueous chemistry is a much cleaner, efficient, cheaper and simple method for synthesis. The scope of reactions was extended to thia-Pictet-Spengler reaction to afford the some isothiochromans.
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Received: 18 August 2009
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| Fund:The author gratefully acknowledges the Higher Education Commission of Pakistan for the financial assistance. |
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Corresponding Authors:
Aamer Saeed,E-mail address:aamersaeed@yahoo.com.
E-mail: aamersaeed@yahoo.com.
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