Abstract An acid catalyzed oxa-Pictet-Spengler reaction ‘on water’ leading to the synthesis of a variety of 1-aryl-6,7-dimethoxyisochro-mans is described. The aqueous chemistry is a much cleaner, efficient, cheaper and simple method for synthesis. The scope of reactions was extended to thia-Pictet-Spengler reaction to afford the some isothiochromans.
Received: 18 August 2009
Fund:The author gratefully acknowledges the Higher Education Commission of Pakistan for the financial assistance.