Abstract A series of novel 4"-O-carbamoyl analogs of clarithromycin were synthesized and evaluated for their in vitro antibacterial activity. All of the desired compounds showed excellent activity against erythromycin-snsceptible S. pneumoniae, Particularly, 4-fluorobenzyl carbamate 7a demonstrated potent activity against erythromycin-resistant S. pneumoniae encoded by the mef gene, and remarkably improved activity against erythromycin-resistant S. pneumoniae encoded by the erm gene, and the erm and mef genes.
Received: 26 August 2009
Fund:This research was supported by Major R&D Program of New Drugs—National S&T Key Special Subject of China (No. 2009ZX09103-115), National Natural Science Foundation of China (No. 20872081) and Natural Science Foundation of Shandong (No. Y2006C31).
Shu Tao Ma,E-mail address:firstname.lastname@example.org