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| CeCl3·7H2O as an efficient catalyst for one-pot synthesis of β-amino ketones by three-component Mannich reaction |
| Yan Daia, Bin Dong Lia, Heng Dao Quanb, Chun Xu Luäa |
a School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;
b National Institute of Advanced Industrial Science and Technology, Ibaraki 3058565, Japan |
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Abstract Cerium trichloride heptahydrate (CeCl3·7H2O) was found to be an efficient and recyclable catalyst for the three-component direct Mannich reaction of anilines and benzaldehydes with acetophenone. This protocol has advantages of high yield, no environmental pollution, mild condition, and simple work-up procedure.
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Received: 13 May 2009
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| Fund:We are grateful for the financial support from Nanjing University of Science and Technology. |
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Corresponding Authors:
Chun Xu Lü,E-mail address:lucx@mail.njust.edu.cn
E-mail: lucx@mail.njust.edu.cn
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