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| Rhodium-catalyzed selective [2+2+2] cyclizations of 1,6-diynes with monoynes leading to isoindolines and isobenzofurans |
| Wei Wu, Xiao Yun Zhang, Shou Xing Kang |
| Department of Chemistry, China University of Petroleum(East China), Qingdao 266555, China |
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Abstract A highly efficient and selective [2+2+2] cyclization of diynes and monoalkynes was catalyzed by rhodium under room temperature in water/THF mixed solvent, affording isoindolines and isobenzofurans in good to excellent yields. The center atoms (N, O) in the diynes showed a significant effect for the cyclization.
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Received: 20 April 2009
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Corresponding Authors:
Wei Wu,E-mail address:wwu257@163.com
E-mail: wwu257@163.com
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