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| Response surface methodology to optimize gradient ion chromatographic separation of inorganic anions and organic acids in tobacco leaves |
| Rui Qi Wanga,b, Na Ni Wangb, Jia Jie Zhangb, Yan Zhub |
a College of Environmental and Biological Engineering, Chongqing Technology and Business University, Chongqing 400067, China;
b Department of Chemistry, Xixi Campus, Zhejiang University, Hangzhou 310028, China |
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Abstract The separation optimization of nine organic and inorganic anions in tobacco leaves using gradient ion chromatography by response surface methodology was investigated. In order to achieve this goal the usefulness of the chromatographic response function (CRF) for the evaluation of the two different chromatographic performance goals (resolution and analysis time) was tested. The experiments were performed according to a Box-Behnken design response surface experimental design.
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Received: 06 April 2011
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| Fund:This research was financially supported by National Natural Science Foundation of China (nos.20775070, J0830413), Zhejiang Provincial Natural Science Foundation of China (no.R4080124). |
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Corresponding Authors:
Jia Jie Zhang,E-mail address:spurs5600@sina.com
E-mail: spurs5600@sina.com
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| About author:: 10.1016/j.cclet.2011.06.011 |
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