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| Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases |
| Wei Honga, James Dowdenb |
a School of Chemistry and Chemical Engineering, Beifang University of Nationalities, Yinchuan 750021, China;
b School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK |
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Abstract Chemically modified cellular co-factors that provide function, such as immobilization or incorporation of fluorescent dyes, are valuable probes of biological activity. A convenient route to obtain S-adenosyl methionine (AdoMet) analogues modified at N-6 adenosine to feature a linker terminating in azide functionality is described herein. Subsequent decoration of such AdoMet analogues with guanidinium terminated linkers leads to novel potential bisubstrate inhibitors for protein arginine methyltransferases, PRMTs.
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Received: 24 May 2011
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| Fund:This work was financially supported by the Medical Research Council Grant (No.G0700840) and the University of Nottingham (Studentship to Wei Hong). |
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Corresponding Authors:
James Dowden,E-mail address:James.Dowden@nottingham.ac.uk
E-mail: James.Dowden@nottingham.ac.uk
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| About author:: 10.1016/j.cclet.2011.09.007 |
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