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| Microwave assisted synthesis of novel Hantzsch 1,4-dihydropyridines, acridine-l,8-diones and polyhydroquinolines bearing the tetrazolo[1,5-a]quinoline moiety and their antimicrobial activity assess |
| Niraj K. Ladani, Divyesh C. Mungra, Manish P. Patel, Ranjan G. Patel |
| Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar 388120, Gujarat, India |
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Abstract Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[l, 5-a]quinoline-4-carbal-dehyde, dimedone/cyclohexane-l, 3-dione, ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[l, 5-a]quinoline based 1, 4-dihydropyridines, acridine-l, 8-diones and polyhydroquinolines. The process presented here is simple, rapid, environmentally welcoming and high yielding. All the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.
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Received: 25 April 2011
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| Fund:The authors are grateful to the Department of Chemistry, S P University, India for providing laboratory facilities. |
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Corresponding Authors:
Divyesh C.Mungra,E-mail address:d_c_mungra@yahoo.co.in
E-mail: d_c_mungra@yahoo.co.in
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| About author:: 10.1016/j.cclet.2011.07.009 |
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Ming-Hua Chen, Sheng Lin, Ya-Nan Wang, Cheng-Gen Zhu, Yu-Huan Li, Jian-Dong Jiang, Jian-Gong Shi. Antiviral stereoisomers of 3,5-bis(2-hydroxybut-3-en-1-yl)-1,2, 4-thiadiazole from the roots of Isatis indigotica[J]. CCL, 2016, 27(05): 643-648. |
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