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A novel and efficient route for the preparation of atorvastatin |
Jian Gaoa, Yang Hui Guob, Ya Ping Wangb, Xiang Jing Wanga, Wen Sheng Xianga |
a Department of Biochemical Engineering, Northeast Agricultural University, Harbin 150030, China; b Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China |
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Abstract A novel and efficient synthetic method of atorvastatin was described. The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction, resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C. This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
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Received: 17 January 2011
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Fund:We are grateful for the financial supports from the National Key Project for Basic Research (No.2010CB11261 02) and the Outstanding Youth Foundation of Heilongjiang Province (No.JC200706). |
Corresponding Authors:
Wen Sheng Xiang,E-mail address:xiangwensheng@yahoo.com.cn
E-mail: xiangwensheng@yahoo.com.cn
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About author:: 10.1016/j.cclet.2011.04.016 |
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