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| Diclofenac derivatives with insulin-sensitizing activity |
| Jian Ta Wang, Ying Wang, Ji Quan Zhang, Xing Cui, Yi Zhang, Gao Feng Zhu, Lei Tang |
| School of Pharmacy, Guiyang Medical College, Guiyang 550004, China |
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Abstract A series of diclofenac derivatives were synthesized. The insulin-sensitizing activity of 28 new compounds was evaluated in 3T3-L1 cells. The compounds 10a and 10f exhibited similar insulin-sensitizing activity with positive drag rosiglitazone.
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Received: 15 July 2010
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| Fund:The research work was supported by National Natural Science Foundation (No. 30960462), Guizhou Social Development Scientific Foundation (No. 2008-3039), Governor's Foundation for Excellent Scientific and Educational Talents of Guizhou (No. 2009-81) and Excellent Youth Scientific Talents Foundation of Guizhou (No. 2009-24). |
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Corresponding Authors:
Lei Tang,E-mail address:tlei1974@hotmail.com
E-mail: tlei1974@hotmail.com
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