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| Design, synthesis and biological evaluation of 1,4-dihydrothieno[3',2':5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists |
| Rui Suna, Jing Songa, Si Jie Liua, Hui Zhaoa, Chun Li Yana, Ai Jun Zhanga, Diwa Koiralab, Da Wei Lib, Chun Hua |
a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, China; Department of Organic Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;
b School of Pharmacy, Shanghai Jiao Tong University, Shanghai 300193, China |
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Abstract The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women, osteoporosis, reproductive cancers such as breast cancer, uterine cancer and prostate cancer. 1,4-Dihydrothieno [3',2':5,6] thiopyrano [4,3-c] pyrazole-3-carboxylic amide derivatives were designed, synthesized and biological evaluated as potential estrogen receptor antagonists.
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Received: 18 June 2010
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| Fund:This work was partially supported by the National Natural Science Foundation of China (NSFC) (No. 20474053). |
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Corresponding Authors:
Chun Hu,E-mail address:chunhu@syphu.edu.cn
E-mail: chunhu@syphu.edu.cn
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| Cite this article: |
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Rui Sun,Jing Song,Si Jie Liu, et al. Design, synthesis and biological evaluation of 1,4-dihydrothieno[3',2':5,6]thiopyrano[4,3-c]pyrazole-3-carboxylic amide derivatives as potential estrogen receptor antagonists[J]. CCL, 2011, 22(03): 256-259.
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| URL: |
| http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2010.10.029 OR http://www.chinchemlett.com.cn/EN/Y2011/V22/I03/256 |
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