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| Synthesis of mono-substituted derivatives of 6-aminoquinoline |
| Tian Lana,b, Xian Xia Yuana, Jiang Hong Yua,c, Chao Jiaa, Yu Shi Wanga, Hui Juan Zhanga, Zi Feng Maa, Wei Dong Yec |
a School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, China;
b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;
c Xinchang Pharmaceutical Factory, Zhejiang Pharmaceutics Co. Ltd., Xinchang 312500, China |
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Abstract Several 6-aminoquinoline derivatives, which could be used in drug design, have been synthesized. The reaction conditions were comparatively studied, and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction. The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.
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Received: 17 June 2010
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| Fund:The authors are grateful for the financial support of this work by the National Science Foundation of China (No. 20776085), the 973 Program of China (No. 2007CB209700), the STCSM of China (Nos. 10JC1406900 and 09XD1402400), the Foundation of Zhejiang Pharmaceutics Co. Ltd. and the Opening Foundation of Zhejiang Provincial Top Key Discipline. |
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Corresponding Authors:
Xian Xia Yuan,E-mail address:yuanxx@sjtu.edu.cn
E-mail: yuanxx@sjtu.edu.cn
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