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| Rapid formation of β-allyl substituted isotetronic acid derivatives via Claisen rearrangement using a microfludic device |
| Xia Ping Ma, Zhi Ming Li, Quan Rui Wang |
| Department of Chemistry, Fudan University, Shanghai 200433, China |
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Abstract The thermal Claisen rearrangement of O-allyl substituted isotetronic acids 1 was successfully carried out within a glass microreactor operated with temperature at 150℃ and a flow rate of 1 mL/h. The strategy provides an efficient alternative way toβ-allyl substituted isotetronic acid derivatives 2 in high yields with much accelerated reaction speed.
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Received: 14 May 2010
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| Fund:The authors would like to thank Ms. Ji Ji for her fruitful discussions and technical assistance. |
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Corresponding Authors:
Quan Rui Wang,E-mail address:qrwang@fudan.edu.cn
E-mail: qrwang@fudan.edu.cn
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