Abstract The thermal Claisen rearrangement of O-allyl substituted isotetronic acids 1 was successfully carried out within a glass microreactor operated with temperature at 150℃ and a flow rate of 1 mL/h. The strategy provides an efficient alternative way toβ-allyl substituted isotetronic acid derivatives 2 in high yields with much accelerated reaction speed.
Received: 14 May 2010
Fund:The authors would like to thank Ms. Ji Ji for her fruitful discussions and technical assistance.
Quan Rui Wang,E-mail address:email@example.com