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A practical synthesis of 2-amino-5-methoxylpropiophenone |
Shan Bao Yua, Li Juan Zhanga, Yu Luoa, Wei Lub |
a Department of Chemistry, East China Normal University, Shanghai 200062, China; b Institute of Drug Discovery and Development, East China Normal University, Shanghai 200062, China |
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Abstract This paper described a practical five-step synthetic approach for 2-amino-5-methoxylpropiophenone in 45% overall yield, using 3-chloropropiophenone as the starting material. The advantages of this procedure include short reaction steps, simple operation and good yield.
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Received: 02 June 2010
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Fund:We gratefully acknowledge the financial support from National Natural Science Foundation of China (No.305722321) and Shanghai Municipal Natural Science Foundation (No.10ZR1409600).We also thank Lab of Organic Functional Molecules,the Sino-French Institute of ECNU for supports. |
Corresponding Authors:
Wei Lu,E-mail address:wlu@chem.ecnu.edu.cn
E-mail: wlu@chem.ecnu.edu.cn
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