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| Glyoxylic acid as catalyst: A simple selective synthesis of 1,2-disubstituted benzimidazoles in aqueous media |
| Shivaji S. Pawara, Deepak V. Dekhanea, Murlidhar S. Shingareb, Shivaji N. Thorea |
a Department of Chemistry, Vinyakrao Patil Mahavidyaia Vaijapur, Aurangabad 423701(M.S.), India;
b Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004(M.S.), India |
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Abstract Glyoxylic acid (5 mol%) performs as a novel highly water-soluble catalyst for the synthesis of 2-aryl-l-arylmethyl-lH-benzimidazoles from a wide range of substituted o-phenylenediamines and various substituted aldehydes in good to excellent isolated yields (85-95%) using water as solvent at ambient temperature. The remarkable advantages offered by this method are easily and inexpensive available catalyst, simple procedure, mild conditions, much faster (20-40 min) reactions and excellent yields of products.
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Received: 21 March 2008
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| Fund:The authors are thankful to Head, Department of Chemistry, Vinayakrao Patil Mahavidyala Vaijapur 423701 (M.S.), India, for partial support of this work. |
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Corresponding Authors:
Shivaji N. Thore,snthore@rediffmail.com
E-mail: snthore@rediffmail.com
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