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| New 3-(4-arylpiperazin-1-yl)-1-(benzo[b]thiophen-3-yl)-2-methylpropanol derivatives: Synthesis and evaluation for dual 5-HT1A/SSRI activities |
| Ai Jun Lia,b, Xiao Hua Zhanga, Xue Qin Zhoua, Dong Zhi Liua |
a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
b College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China |
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Abstract A series of 3-(4-arylpiperazin-1-yl)-l-(benzo[b]thiopben-3-yl)-2-methylpropanol derivatives were designed and synthesized based on 5-HT1A/SSRI drugs design strategies.The synthesized compounds were evaluated for their dual 5-HT1A/5-HTT activities.
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Received: 08 November 2007
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| Fund:This work was supported by the National Natural Science Foundation of China (No. 20576094). We also thank Prof. Naihong Chen for determining affinity to 5-HTT and 5-HT1A receptor. |
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Corresponding Authors:
Dong Zhi Liu,E-mail address:liaj@yeah.net
E-mail: liaj@yeah.net
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