|
|
|
| Arylpiperazine derivatives of diphenylsulfide: Synthesis and evaluation for dual 5-HT1A/SSRI activities |
| Xue Dan Wua, Dong Zhi Liua, Ai Jun Lia,b, Xue Qin Zhoua |
a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
b College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China |
|
|
|
|
Abstract The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5-HT1A/SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5-HT1A affinity. Compound 13a shows moderate dual activities and is a promising lead compound for further structure-activity relationships studies.
|
|
Received: 05 November 2007
|
| Fund:This work was supported by the National Natural Science Foundation of China (No. 20576094). We also thank Prof. Chen Naihong for determining affinity for the 5-HTT and 5-HT1A receptor. |
|
Corresponding Authors:
Ai Jun Li,E-mail address:lajd@tju.edu.cn
E-mail: lajd@tju.edu.cn
|
|
|
|
|
|
|
