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| The simple synthesis of quinazoline-2,4-dione derivatives using Boc strategy |
| Xu Qin Li |
| School of Applied Science, University of Science and Technology Beijing, Beijing 100083, China |
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Abstract Quinazolinediones are particularly attractive pharmacophores because of their wide range of bioactivities.A convenient synthetic pathway to three-substituted quinazoline-2,4-dione derivatives was developed from substituted anthranilamide via carbonylation with Boc anhydride and then cyclization in the presence of the base sodium methoxide.Good to excellent yields have been achieved.
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Received: 17 March 2009
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| Fund:The Project Sponsored by Beijing Nova Program (No.2008B20) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars;State Education Ministry (No.11140058). |
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Corresponding Authors:
Xu Qin Li,E-mail address:xuqinli1977@gmail.com.
E-mail: xuqinli1977@gmail.com.
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