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| 1-Heptanesulfonic acid sodium salt:One pot efficient synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzo[d]imidazoles |
| Ganesh R. Jadhava,b, Mohammad U. Shaikhb, Rajesh P. Kaleb, Charansingh H. Gilla |
a Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004, India;
b Division of Medicinal Chemistry, Wockhardt Research Centre, D-4, Chikalthana M.I.D.C. Area, Aurangabad, Maharashtra, 431210, India |
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Abstract Synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzo[d]imidazoles by the reaction of o-phenylenediamine with substituted aromatic aldehydes in the presence of 1-heptanesulfonic acid sodium salt (10 mol%) at room temperature. The reactions were performed in acetonitrile:water (8:2). The method was proved to be eco-friendly, convenient and the products were isolated with good yields (82-90%).
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Received: 13 October 2008
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| Fund:The authors are thankful to The Director, Wockhardt research Centre, Aurangabad Maharashtra, India and The Head of Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, for their valuable support and laboratory facility. |
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Corresponding Authors:
Charansingh H. Gill,E-mail:chgill50@gmail.com
E-mail: chgill50@gmail.com
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