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New C20-diterpenoid alkaloids from Aconitum sinomontanum |
Hua Tang, Fu-Li Wen, Shu-He Wang, Xiao-Yu Liu, Dong-Lin Chen, Feng-Peng Wang |
Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041, China |
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Abstract Two new denudatine-type C20-diterpenoid alkaloids, named sinomontanidines A (1) and B (2), were isolated from the roots of Aconitum sinomontanum Nakai. Their structures were elucidated by extensive analysis of 1D, 2D NMR, and MS data.
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Received: 09 November 2015
Published: 28 February 2016
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Fund:This research was financially supported by the National Natural Science Foundation of China (No. 81273387). |
Corresponding Authors:
Dong-Lin Chen, Feng-Peng Wang
E-mail: chendl@scu.edu.cn;wfp@scu.edu.cn
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[1] |
W.T. Wang, P.G. Xiao, Aconitum sinomontanum Nakai, in:Flora of China, Vol. 27, Science Press, Beijing, 1979, pp. 168-170.
|
[2] |
S.Y. Chen, Y.Q. Liu, C.R. Yang, Chemical constituent of Aconitum sinomontanum Nakai, Acta Bot. Yunnan 2(1980) 473-475.
|
[3] |
B.Y. Wei, X.W. Kong, Z.Y. Zhao, et al., The research of Chinese Aconitum XVIII, Zhong Yao Tong Bao 6(1981) 26-28.
|
[4] |
C.S. Peng, J.Z. Wang, X.X. Jan, et al., Alkaloids of Aconitum sinomontanum and Aconitum racemulosum franch var. pengzhouense, Nat. Prod. Res. Dev. 12(2000) 45-51.
|
[5] |
C.S. Peng, F.P. Wang, J.Z. Wang, et al., Two new bisnorditerpenoid alkaloids sinomontanines D and E from Aconitum sinomontanum, Acta Pharm. Sin. 35(2000) 201-203.
|
[6] |
C.S. Peng, D.L. Chen, Q.H. Chen, F.P. Wang, New diterpenoid alkaloids from roots of Aconitum sinomontanum, Chin. J. Org. Chem. 25(2005) 1235-1239.
|
[7] |
C.L. Yuan, X.L. Wang, Isolation of active substances and bioactivity of Aconitum sinomontanum Nakai, Nat. Prod. Res. 26(2012) 2099-2102.
|
[8] |
B. Xu, J. Xue, J. Tan, et al., Two new alkaloids from the roots of Aconitum sinomontanum Nakai, Helv. Chim. Acta 97(2014) 727-732.
|
[9] |
F.P. Wang, Q.H. Chen, X.Y. Liu, Diterpenoid alkaloids, Nat. Prod. Rep. 27(2010) 529-570.
|
[10] |
X.Y. Liu, Q.H. Chen, F.P. Wang, Three new C20-diterpenoid alkaloids from Delphinium anthriscifolium var. savatieri, Chin. Chem. Lett. 20(2009) 698-701.
|
[11] |
L. Lin, D.L. Chen, X.Y. Liu, et al., Trichocarpinine, a novel hetidine-hetisine type bisditerpenoid alkaloid from Aconitum tanguticum var. trichocarpum, Helv. Chim. Acta 93(2010) 118-122.
|
[12] |
D.L. Chen, P. Tang, Q.H. Chen, F.P. Wang, New C20-diterpenoid alkaloids from Delphinium laxicymosum var. pilostachyum, Nat. Prod. Commun. 9(2014) 623-625.
|
[13] |
Z.T. Zhang, X.Y. Liu, D.L. Chen, F.P. Wang, Three new C20-diterpenoid alkaloids from Aconitum tanguticum var. trichocarpum, Nat. Prod. Commun. 10(2015) 861-862.
|
[14] |
Q. Mei, Y.N. Wang, M. Zhao, et al., 1H-15N HMBC spectra of C18-diterpenoid alkaloids, Chin. Chem. Lett. 26(2015) 804-806.
|
[15] |
F.P. Wang, X.T. Liang, C20-diterpenoid alkaloids, in:G.A Cordell (Ed.), The Alkaloids:Chemistry and Biology, Vol. 59, Elsevier, New York, 2002, pp. 1-280.
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