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Synthesis, antimicrobial and anti-inflammatory activities of some novel 5-substituted imidazolone analogs |
Ashwani Kumar Dhingraa,b, Bhawna Chopraa,b, Rameshwar Dassc, Sanjeev Kumar Mittald |
a Guru Gobind Singh College of Pharmacy, Yamuna Nagar 135001, Haryana, India;
b Department of Pharmacy, IK Gujral Punjab Technical University, Jalandhar 144001, Punjab, India;
c Department of Industrial Chemistry, Guru Nanak Khalsa College, Yamuna Nagar 135001, Haryana, India;
d IEC School of Pharmacy, IEC University, Baddi 173205, Himachal Pardesh, India |
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Abstract In view of potent antimicrobial and anti-inflammatory activities exhibited by 5-substituted imidazolones, a variety of novel imidazolone analogs 3a-l were synthesized by the condensation of different substituted oxazolones 1 with various aromatic amines 2. All the synthesized compounds were screened for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Several analogs produced good or moderate activities particularly against the tested Gram-positive bacteria Micrococcus luteus and Gram-negative bacteria Pseudomonas aeruginosa and. Meanwhile, compounds 3b and 3c displayed marked antifungal activity against C. albicans. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. Two of 5-substituted imidazolone derivatives, 3k and 3d show good anti-inflammatory activity. The structures of all the newly synthesized compounds were elucidated using IR, 1H NMR and 13C NMR.
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Received: 18 June 2015
Published: 06 February 2016
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Corresponding Authors:
Ashwani Kumar Dhingra
E-mail: ashwani1683@gmail.com
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