Synthesis, antimicrobial and anti-inflammatory activities of some novel 5-substituted imidazolone analogs

doi:10.1016/j.cclet.2016.01.049

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Abstract In view of potent antimicrobial and anti-inflammatory activities exhibited by 5-substituted imidazolones, a variety of novel imidazolone analogs 3a-l were synthesized by the condensation of different substituted oxazolones 1 with various aromatic amines 2. All the synthesized compounds were screened for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. Several analogs produced good or moderate activities particularly against the tested Gram-positive bacteria Micrococcus luteus and Gram-negative bacteria Pseudomonas aeruginosa and. Meanwhile, compounds 3b and 3c displayed marked antifungal activity against C. albicans. In addition, the in vivo anti-inflammatory activity of the synthesized compounds was determined using the carrageenin-induced paw oedema method in rats. Two of 5-substituted imidazolone derivatives, 3k and 3d show good anti-inflammatory activity. The structures of all the newly synthesized compounds were elucidated using IR, ¹H NMR and ¹³C NMR.

Key words： Oxazolones Imidazolones Antimicrobial activity Anti-inflammatory activity

Received: 18 June 2015 Published: 06 February 2016

Corresponding Authors: Ashwani Kumar Dhingra E-mail: ashwani1683@gmail.com

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http://www.chinchemlett.com.cn/EN/10.1016/j.cclet.2016.01.049 OR http://www.chinchemlett.com.cn/EN/Y2016/V27/I05/707

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